Octamer-binding transcription factor 4

Octamer-binding transcription factor 4

Oct-4 is a homeodomain transcription factor of the POU family.\
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HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice.

Our previous studies showed that intranasal administration of a histone deacetylase inhibitor sodium butyrate (NaB) demonstrated a therapeutic effect in a mouse model of allergic rhinitis (AR). However, whether the AR NaB effective when administered orally and prophylaxis, as well as the potential effects on gene expression, remains unknown. This study aims to determine the preventive effects of NaB in AR when added to the newly weaned mice a diet and to evaluate changes in the length of the non-coding (Inc.) RNA and mRNA expression profiles in the nasal mucosa.

Rats were randomly divided into three groups as follows: i) Control (C) group (no treatment); ii) AR group [treated with ovalbumin (OVA)]; and iii) NaB + AR group (treated with OVA and NaB). NaB + AR group was given NaB in their feed (30 g / kg chow), while the other two groups were fed a normal feed between 3 and 6 weeks of age. At 7 weeks of age, the administration of OVA starts to push the AR in AR group and NaB + AR. Following the formation of models, behavioral assessment, western blotting and gene expression analysis performed. NaB exhibited preventive effect in a murine model AR, reduced the increase in histone deacetylase 1 (HDAC1) and HDAC8 expression and an increase in OVA-induced acetylation of histone H3 at lysine 9.

In addition, the increase AR-related NaB low expression of interleukin 2 (IL-2) , interferon-γ and IL-17 and IL-lowering expression of 4 , IL-5 and transforming growth factor β1. Gen Ontology and pathway analysis revealed the top 10 lines between groups. Octamer – bind transcription factor 1, ecotropic viral integration site 1 and box paired 4 predicted to be a target gene lncRNA (NONMMUT057309). Thus, NaB may show a preventive effect on AR. Additionally, lncRNA and mRNA expression profiles in rat nasal mucosa with AR significantly different after NaB treatment. These results may provide insight into the pathogenesis of AR and suggest new treatment targets.

HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice.
HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice.

Ethyl-p-methoxycinnamate Improve and strengthen pluripotency Oct4 expression through the NF-kB signaling pathway.

The stem cells are pluripotent which have therapeutic applications in regenerative medicine and drug discovery. However, stem cell differentiation in vitro and inhibit the production of large-scale clinical application. Maintenance of cell pluripotency depends upon a complex network of transcription factor ; This, octamer – bind transcription factor – 4 (October 4 ) plays a key role. This study aims to establish an October 4 promoter-driven reporter gene firefly luciferase and screen small molecule compounds could maintain cell self-renewal and pluripotency.

The results showed that ethyl-p-methoxycinnamate (EPMC) increase promoter activity in October 4 gene, upregulated in October 4 at both mRNA and protein levels, and significantly promoted the formation of colonies P19 cells.

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These findings indicate that EPMC may reinforce self-renewal capacity of P19 cells. Pluripotency markers October 4 , SRY-related high-mobility group box protein-2, and Nanog are expressed at higher levels in the colonies EPMC-induced. EPMC can promote the formation of teratomas and P19 cell differentiation potential in vivo. It also enhanced self-renewal and pluripotency of human umbilical cord mesenchymal stem cells and mouse embryonic stem cells.