Octamer-binding transcription factor 4

Octamer-binding transcription factor 4

Oct-4 is a homeodomain transcription factor of the POU family.\
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HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice.

Our previous studies showed that intranasal administration of a histone deacetylase inhibitor sodium butyrate (NaB) demonstrated a therapeutic effect in a mouse model of allergic rhinitis (AR). However, whether the AR NaB effective when administered orally and prophylaxis, as well as the potential effects on gene expression, remains unknown. This study aims to determine the preventive effects of NaB in AR when added to the newly weaned mice a diet and to evaluate changes in the length of the non-coding (Inc.) RNA and mRNA expression profiles in the nasal mucosa.

Rats were randomly divided into three groups as follows: i) Control (C) group (no treatment); ii) AR group [treated with ovalbumin (OVA)]; and iii) NaB + AR group (treated with OVA and NaB). NaB + AR group was given NaB in their feed (30 g / kg chow), while the other two groups were fed a normal feed between 3 and 6 weeks of age. At 7 weeks of age, the administration of OVA starts to push the AR in AR group and NaB + AR. Following the formation of models, behavioral assessment, western blotting and gene expression analysis performed. NaB exhibited preventive effect in a murine model AR, reduced the increase in histone deacetylase 1 (HDAC1) and HDAC8 expression and an increase in OVA-induced acetylation of histone H3 at lysine 9.

In addition, the increase AR-related NaB low expression of interleukin 2 (IL-2) , interferon-γ and IL-17 and IL-lowering expression of 4 , IL-5 and transforming growth factor β1. Gen Ontology and pathway analysis revealed the top 10 lines between groups. Octamer – bind transcription factor 1, ecotropic viral integration site 1 and box paired 4 predicted to be a target gene lncRNA (NONMMUT057309). Thus, NaB may show a preventive effect on AR. Additionally, lncRNA and mRNA expression profiles in rat nasal mucosa with AR significantly different after NaB treatment. These results may provide insight into the pathogenesis of AR and suggest new treatment targets.

HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice.
HDAC inhibitor sodium butyrate prevents allergic rhinitis and alters lncRNA and mRNA expression profiles in the nasal mucosa of mice.

Ethyl-p-methoxycinnamate Improve and strengthen pluripotency Oct4 expression through the NF-kB signaling pathway.

The stem cells are pluripotent which have therapeutic applications in regenerative medicine and drug discovery. However, stem cell differentiation in vitro and inhibit the production of large-scale clinical application. Maintenance of cell pluripotency depends upon a complex network of transcription factor ; This, octamer – bind transcription factor – 4 (October 4 ) plays a key role. This study aims to establish an October 4 promoter-driven reporter gene firefly luciferase and screen small molecule compounds could maintain cell self-renewal and pluripotency.

The results showed that ethyl-p-methoxycinnamate (EPMC) increase promoter activity in October 4 gene, upregulated in October 4 at both mRNA and protein levels, and significantly promoted the formation of colonies P19 cells.

Human IgM ELISA kit

E22-HC019.48 48T
EUR 295

Human IgM ELISA kit

E22-HC019.96 96T
EUR 395

Human IgM ELISA kit

F170 1 kit (96 wells plate)
EUR 1056
Description: Human IgM ELISA kit by Cygnus Technologies is available in Europe via Gentaur.

Human IgM ELISA Kit

E28L0255 96T
EUR 666.67

Human IgM ELISA Kit

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Human IgM ELISA Kit

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Human IgM ELISA KIT

E42EH-154 96T/48T Ask for price

Human IgM ELISA Kit

ELA-E0543h 96 Tests
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Human IgM ELISA Kit

DEIA691 96T
EUR 752.4
Description: This Kit is a highly sensitive twosite enzyme linked immunoassay (ELISA) for measuring IgM in Human biological samples.

Human (IgM) ELISA kit

E01A1252 96T
EUR 700
Description: ELISA

Human (IgM) ELISA kit

E01A1876-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human (IgM) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human (IgM) ELISA kit

E01A1876-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human (IgM) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human (IgM) ELISA kit

E01A1876-96 1 plate of 96 wells
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Description: A sandwich ELISA for quantitative measurement of Human (IgM) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human IgM ELISA Kit

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EUR 625.2

Human IgM ELISA Kit

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Human IgM ELISA kit

55R-1920 96 tests
EUR 508
Description: ELISA Kit for detection of IgM in the research laboratory

Human IgM ELISA Kit

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*Human IgM ELISA Kit

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Description: *Human IgM ELISA Kit

Human IgM ELISA Kit

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Human Rotavirus IgM (RV IgM) ELISA Kit

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Human Rotavirus IgM (RV IgM) ELISA Kit

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Human Hantavirus IgM(HV- IgM) Elisa Kit

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Human Hantavirus IgM(HV- IgM) ELISA Kit

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Human Occludin IgM (OCLN IgM) ELISA Kit

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Human Occludin IgM (OCLN IgM) ELISA Kit

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human EchoVirus IgM,ECHO IgM ELISA Kit

201-12-1763 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human EchoVirus IgM(ECHO IgM) Elisa Kit

EK700521 96 Wells
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Human EchoVirus IgM(ECHO IgM)ELISA Kit

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Human EchoVirus IgM(ECHO IgM)ELISA Kit

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Human EchoVirus IgM(ECHO IgM)ELISA Kit

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Human EchoVirus IgM,ECHO IgM ELISA Kit

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Human Leptospira IgM,Lep IgM ELISA Kit

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Human Adenovirus IgM (ADV IgM) ELISA Kit

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Human measlesvirus IgM,MV IgM ELISA kit

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EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

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Human measlesvirus IgM(MV IgM)ELISA Kit

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IgM ELISA KIT|Human

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Human Papillomavirus IgM (HPV IgM) ELISA Kit

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Human Measles Virus IgM (MV IgM) ELISA Kit

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Human RF IgM ELISA Kit

DEIA1697 96T
EUR 836.4
Description: The Rheumatoid Factor (RF) IgM ELISA test system is intended for the qualitative and semi-quantitative detection of RF IgM-class antibody in human serum. The test system is intended to be used as an aid in the diagnosis of rheumatoid arthritis.

Human RF IgM ELISA Kit

DEIA1810 96T
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Description: Rheumatoid Factor IgM is an indirect solid phase enzyme immunoassay ( ELISA ) for the quantitative measurement of IgM class rheumatoid factor antibodies in human serum or plasma. The assay is intended for in vitro diagnostic use only as an aid in the determination of rheumatoid arthritis ( RA ).

Human MP IgM ELISA Kit

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Human EB IgM ELISA Kit

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Human IM IgM ELISA Kit

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Human Fasciola Hepatica IgM(FH IgM)ELISA Kit

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Human Monkeypox Virus IgM (MPXV IgM) ELISA Kit

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Human Rotavirus antibody IgM(RV IgM) Elisa Kit

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Human Coxsackievirus A16 IgM (CA16 IgM) ELISA Kit

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201-12-1068 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

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Human Parainfluenza Virus IgM (HPIV IgM) ELISA Kit

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Human Mycoplasma Pneumoniae IgM (MP IgM) ELISA Kit

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Human Typhoid antibody IgM (Typhoid- IgM)ELISA Kit

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Human RF-IgM(Rheumatoid Factor IgM) ELISA Kit

EH4271 96T
EUR 628.92
Description: Method of detection: Indirect ELISA;Reacts with: Homo sapiens;Sensitivity: 2.813IU/ml

Human HDV IgM ELISA Kit

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EUR 1026
Description: The Human HDV IgM ELISA Kit is an enzyme-linked immunosorbent assay for qualitative determination of IgM-class antibodies to hepatitis D virus in human serum or plasma.

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EUR 661.2
Description: Enzyme Immunoassay for the Detection of IgM antibodies to Cytomegalovirus in Human Serum.

Human PIV IgM ELISA Kit

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EUR 625.2

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Human IgM GENLISA ELISA

KBH0187 1 x 96 wells
EUR 286

Human Anticardiolipin Antibody IgM (aCL IgM) ELISA Kit

abx354314-96tests 96 tests
EUR 943.2

Human Anticardiolipin Antibody IgM (aCL IgM) ELISA Kit

abx253448-96tests 96 tests
EUR 764.4

Human SRBC IgM ELISA kit

E01S0453-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human SRBC IgM in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human SRBC IgM ELISA kit

E01S0453-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human SRBC IgM in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human SRBC IgM ELISA kit

E01S0453-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human SRBC IgM in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human HRAb IgM  ELISA Kit

NSL1994Hu 96 wells
EUR 468

Human ebola IgM ELISA Kit

SL3340Hu 96 Tests
EUR 468

Human Rift Valley Fever IgM (RVF IgM) ELISA Kit

KTE62979-48T 48T
EUR 359
Description: Human Rift Valley Fever IgM (RVF IgM) ELISA Kit quantitates Human RVF IgM in samples.

Human Rift Valley Fever IgM (RVF IgM) ELISA Kit

KTE62979-96T 96T
EUR 619
Description: Human Rift Valley Fever IgM (RVF IgM) ELISA Kit quantitates Human RVF IgM in samples.

Human Rift Valley Fever IgM (RVF IgM) ELISA Kit

KTE62979-96T5 96 T×5
EUR 2809
Description: Human Rift Valley Fever IgM (RVF IgM) ELISA Kit quantitates Human RVF IgM in samples.

Human Rift Valley Fever IgM (RVF IgM) ELISA Kit

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EUR 26209
Description: Human Rift Valley Fever IgM (RVF IgM) ELISA Kit quantitates Human RVF IgM in samples.

Human Anti-PEG IgM ELISA

KT-1897 96 tests
EUR 778

Human IgM ELISA (96 Determinations)

0801183 96T
EUR 432

Human IgM ELISA (96 Determinations)

801183 96 Determinations
EUR 432

Human Hepatitis D virus IgM,HDV IgM ELISA Kit

201-12-1581 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Hepatitis D virus IgM(HDV IgM)ELISA Kit

GA-E1597HM-48T 48T
EUR 346.8

Human Hepatitis D virus IgM(HDV IgM)ELISA Kit

GA-E1597HM-96T 96T
EUR 559.2

Human Hepatitis D virus IgM,HDV IgM ELISA Kit

EK0217 96 tests
EUR 789

Human Hepatitis A Virus IgM (HAV IgM) ELISA Kit

abx364864-96tests 96 tests
EUR 548.4

Human Hepatitis E Virus IgM (HEV IgM) ELISA Kit

abx364865-96tests 96 tests
EUR 548.4

Human Influenza A Virus IgM (AIV IgM) ELISA Kit

abx364869-96tests 96 tests
EUR 651.6

Human Influenza B Virus IgM (BIV IgM) ELISA Kit

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EUR 651.6

Human Hepatitis A Virus IgM (HAV IgM) ELISA Kit

abx257503-96tests 96 tests
EUR 764.4

Human Hepatitis D virus IgM(HDV IgM)ELISA Kit

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Human Hepatitis A Virus IgM (HAV IgM) ELISA Kit

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Human bocavirus IgM(BC-IgM) ELISA Kit

SL2684Hu 96 Tests
EUR 468

Human Typhoid IgM Elisa Kit

EK710892 96 Wells
EUR 0.12

Human Rubella IgM ELISA Kit

IHURBAIGMKT each
EUR 422
Description: Human Rubella IgM ELISA Kit

Human Endocab- IgM ELISA Kit

SL2461Hu 96 Tests
EUR 468

Human Marburg IgM ELISA Kit

SL3342Hu 96 Tests
EUR 468

Human Malaria IgM  ELISA Kit

SL3733Hu 96 Tests
EUR 468

Human Membrane IgM ELISA kit

E01A5913 96T
EUR 700
Description: ELISA

Human Membrane IgM ELISA kit

E01M0351-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Membrane IgM in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Membrane IgM ELISA kit

E01M0351-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Membrane IgM in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Membrane IgM ELISA kit

E01M0351-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Membrane IgM in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Brucella IgM ELISA Kit

SL2196Hu 96 Tests
EUR 468

Human Brucella IgM ELISA Kit

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Human Hantavirus IgM (HV-IgM) ELISA Kit

abx055453-96tests 96 tests
EUR 801.6

Human Rhinovirus IgM (RV-IgM)ELISA Kit

SL3088Hu 96 Tests
EUR 468

Human Parvovirus IgM, PV-IgM ELISA Kit

SL3844Hu 96 Tests
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These findings indicate that EPMC may reinforce self-renewal capacity of P19 cells. Pluripotency markers October 4 , SRY-related high-mobility group box protein-2, and Nanog are expressed at higher levels in the colonies EPMC-induced. EPMC can promote the formation of teratomas and P19 cell differentiation potential in vivo. It also enhanced self-renewal and pluripotency of human umbilical cord mesenchymal stem cells and mouse embryonic stem cells.