Adult stem cells age during long-term culture in vitro, and neural stem cells (NSC), which can renew themselves and differentiate into neurons and glial cells, also in the show reduces the differentiation potential after repeated passaging. However, the mechanistic details underlying this process remains unclear.

In this study, we found that the long-term in vitro culture of NSCs resulted inflammatory- aging-associated upregulation and endoplasmic reticulum (ER) stress-related genes, including the proinflammatory cytokines interleukin (IL) 1β and IL6, which senescence- enzyme-linked matrix metallopeptidase 13 (MMP13), and ER stress-responsive transcription factor activating transcription factor 4 (ATF 4 ) and C / EBP homologous protein (CHOP).

However, the induction of cyclic and while the four reprogramming factor (POU domain, class 5, transcription factor 1, also known as octamer < / em> – bind transcription factor 4 ; SRY [sex determination region Y] -box 2; Kruppel – such as factor 4 , and myelocytomatosis oncogene; collectively referred to as OSKM) can inhibit the aging of the NSC, as indicated by a decrease in the expression of genes related to inflammation and ER stress.

We use ROSA- 4 F NSC, which revealed OSKM only one allele, to minimize the potential for full reprogramming or formation of tumors during NSC rejuvenation. We hope that this novel method of rejuvenation will increase the potential of NSCs as a clinical approach to the treatment of neurological diseases. True hermaphroditism with dysgerminomas: A case report ntroduction:

Inhibition of neural stem cell aging through the transient induction of reprogramming factors
Inhibition of neural stem cell aging through the transient induction of reprogramming factors

True hermaphroditism is a rare disorder and is usually sporadic.

It is defined by the presence of both ovaries and testes tissue together as ovotestis.Patient concerns: In this study, we report a rare case of true hermaphroditism with dysgerminomas. A 4 9 year old woman developed a mass in the inguinal region for 30 years. Recently three months, patients find that the size of the mass in her left inguinal region increased significantly.


Diagnosis: After surgical resection, the results of immunohistochemistry mass of the left reveals dysgerminomas with positive expression of placental alkaline phosphatase and octamer – bind transcription factor 3 / 4 , and the mass of the right is cryptorchidism a. chromosome analysis revealed a karyotype 4 6, XY. The combined immunohistochemistry and karyotype analysis, the diagnosis of true hermaphroditism with dysgerminomas made.


Intervention: Radiotherapy combined with chemotherapy after resection of the tumor used to improve his prognosis. Hormone replacement therapy with conjugated estrogens and medroxyprogesterone acetate is used to maintain her female characteristics.
Results: Patients undergoing hormone replacement and has been well over 6 months.

Hamster IgG, purified (Armenian, Isotype control)

20003-1AH 1 mg
EUR 263

G. Pig IgG Fc-Biotin conjugate (isotype control, non-immune) purified

20004-3-B 0.1 mg
EUR 225

G. Pig IgG-Biotin conjugate (isotype control)

20004-B 100 ug
EUR 202

Rat IgG F(ab')2 fragment, purified (isotype control)

20005-1-FAB2 1 mg
EUR 202

Rat IgG (Fc)-Biotin Conjuagte (isotype control), purified

20005-1-FC-B 0.1 mg
EUR 225

Rat IgG1-Biotin conjugate (isotype control)

20005-11-B 100 ug
EUR 202

Rat IgG2a-APC conjugate (isotype control)

20005-12-APC 25 tests
EUR 202

Rat IgG2a-Biotin conjugate (isotype control)

20005-12-B 100 ug
EUR 202

Rat IgG2b-Biotin conjugate (isotype control)

20005-13-B 100 ug
EUR 202

Rat IgG2c-Biotin conjugate (isotype control)

20005-14-B 100 ug
EUR 225

Rat IgM-Biotin conjugate (isotype control)

20005-21-B 100 ug
EUR 225

Rat IgG-Agarose conjugate(aff matrix)

20005-AS-1 0.5 ml
EUR 164

Rat IgG-Biotin conjugate (isotype control) (Isotype control)

20005-B 100 ug
EUR 164

Sheep IgG-Biotin Conjugate (isotype control, non-immune), purified

20006-1-B 0.5 mg
EUR 202

Sheep IgM-Biotin Conjugate (non-immune) control, purified

20006-2-B 0.1 mg
EUR 225

Sheep IgG Fc-Biotin Conjugate (isotype control, non-immune), purified

20006-4-B 0.5 mg
EUR 202

Human IgG-Biotin conjugate (isotype control, non-immune), purified

20007-1-B 0.5 mg
EUR 225

Human IgG (>98%, non-immune, control, Liquid @ 10 mg/ml, azide free, bulk size)

20007-1-BL-1 10 ml Ask for price

Human IgG (>98%, non-immune, control, powder, azide free, bulk size)

20007-1-BP-1 1 g
EUR 651

Human IgG (>98%, non-immune, control, powder, azide free, bulk size)

20007-1-BP-10 10 g
EUR 4313

Human IgG Fab fragment-Biotin Conjugate, purified

20007-1-FAB-B 0.1 mg
EUR 202

Human IgG F(ab')2 fragment, purified

20007-1-FAB2 1 mg
EUR 202

Human IgG Fab2 fragment-Biotin Conjugate, purified

20007-1-FAB2-B 0.1 mg
EUR 202

Human IgG Fc-Biotin conjugate (isotype control, non-immune), purified

20007-1-Fc-B 0.1 mg
EUR 164

Human IgG (Fc) fragment, purified (>95%, low endotoxin)

20007-1-FC-LE 100 ul
EUR 225

Human IgG (Fc) fragment-Biotin purified (>95%, low endotoxin)

20007-1-FC-LE-B 25 ug
EUR 286

Human IgG (serum origin, purified >97%, low endotoxin, azide free)

20007-1-LE-1 1 mg
EUR 164

Human IgG-Biotin (serum origin, purified >97%, low endotoxin, azide free)

20007-1-LE-BTN 100 ug
EUR 286

TruStrip RDT Human IgG Rapid test cards, 10/pk

20007-1-RDT 1 Pk
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TruStrip RDT Human IgG Rapid test cards, 25/pk

20007-1-RDT-25 1 Pk
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Human IgM, purified (native, isotype control, >96% pure, ELISA Grade)

20007-2 1 mg
EUR 164

Human IgM purified (isotype control, >96% pure, ELISA Grade)

20007-2-10 10 mg
EUR 895

Human IgM purified (isotype control, >96% pure, ELISA Grade)

20007-2-5 5 mg
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Human IgM (myeloma, >96%, non-immune, control; bulk size)

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Human IgM (myeloma, >96%, non-immune, control; bulk size)

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Human IgM-Biotin conjugate (myeloma, isotype control)

20007-2-MB 100 ug
EUR 164

Human IgM (Rheumatoid Factor plasma, >40,000 IU/ml, purifed for ELISA)

20007-2-RF 100 ul
EUR 469

Human IgE (myeloma, kappa), purified (isotype control, >95%, low endotoxin, azide free)

20007-3-LE-50 100 ug
EUR 408

Human IgE-Biotin (myeloma, kappa), purified (isotype control, >95%, low endotoxin, azide free)

20007-3-LE-BTN 100 ul
EUR 408

Human IgM Fab mu fragment (myeloma)-Biotin conjugate (isotype control)

20007-4-B 100 ug
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Human IgG-Fc fragment (97%, low endotoxin, azide free)

20007-F-LE-100 100 ug
EUR 164

Human IgG-Fc fragment-Biotin (97%, low endotoxin, azide free)

20007-F-LE-BTN 100 ug
EUR 286

Human IgG1-Biotin Conjugate (-ve control)

20007-G1-B 100 ug
EUR 164

Recombinant (HEK) Human IgG1 Fc (103Cys/Ser, 99-330aa, His-tag, >95%, low endotoxin)

20007-G1-FC 50 ug
EUR 286

Human IgG2-Biotin Conjugate

20007-G2-B 100 ug
EUR 164

Recombinant (HEK) Human IgG2-Fc (257Ser/Ala, 99-327aa, His-tag, >95%, low endotoxin)

20007-G2-FC 50 ug
EUR 286

Human IgG3-Biotin Conjugate

20007-G3-B 100 ug
EUR 164

Recombinant (HEK) Human IgG3-Fc (99-377aa, His-tag, >95%, low endotoxin)

20007-G3-FC 50 ug
EUR 286

Human IgG4-Biotin Conjugate

20007-G4-B 100 ug
EUR 164

Recombinant (HEK) Human IgG4-Fc (108Ser/Pro, 99-327aa, His-tag, >95%, low endotoxin)

20007-G4-FC 50 ug
EUR 286

Mouse IgG F(ab')2 fragment, purified

20008-1-Fab2 1 mg
EUR 202

Mouse IgG (>97%, ELISA/RIA/Diagnostic Grade; -ve mouse viruses & Protein A/G free)

20008-1-WA 1 mg
EUR 164

Mouse IgG-Agarose conjugate (aff matrix)

20008-AS-1 0.5 ml
EUR 164

Mouse IgG-Biotin conjugate (isotype control)

20008-B 50 Tests
EUR 164

Mouse IgG-Biotin conjugate (isotype control)

20008-BT-1 1 mg
EUR 164

Mouse IgG Fab-Biotin conjugate (isotype control)

20008-Fab-B 100 ug
EUR 164

Mouse IgG F(ab')2-Biotin conjugate (isotype control)

20008-Fab2-B 100 ug
EUR 164

Mouse IgG F(ab')2-FITC conjugate (isotype control)

20008-Fab2-F 100 ug
EUR 164

Mouse IgG F(ab')2-HRP conjugate (isotype control)

20008-Fab2-HP 100 ug
EUR 164

Mouse IgG F(c)-Biotin conjugate (isotype control)

20008-Fc-B 100 ug
EUR 164

Rabbit IgG Fab-Biotin Conjugate, purified

20009-1-FAB-B 0.1 mg
EUR 202

Rabbit IgG F(ab')2 fragment, purified

20009-1-FAB2 1 mg
EUR 202

Recombinant (HEK) Rabbit IgG (Fc) (101-323aa, 185Thr/Asn284Ser, ~33 kda, >95%, Low Endotoxin)

20009-1-R-FC 50 ug
EUR 286

Rabbit IgM-Biotin Conjugate (isotype control, non-immune), purified

20009-2-1-B 0.1 mg
EUR 225

Rabbit IgA-Biotin Conjugate (isotype control, non-immune), purified

20009-3-1-B 0.1 mg
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Rabbit IgG-Agarose conjugate

20009-AS-1 0.5 ml
EUR 164

Rabbit IgG (Whole, non-immune)-Biotin conjugate

20009-B 100 ug
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Rabbit IgG-biotinylated (isotype control)

20009-BT-1 1 mg
EUR 286

Rabbit IgG F(ab')2-biotin conjugate, isotype control

20009-FAb2-B 100 ug
EUR 164

Rabbit IgG F(ab')2-FITC conjugate, isotype control

20009-FAb2-F 100 ug
EUR 164

Rabbit IgG F(ab')2-HRP conjugate, isotype control

20009-FAb2-HP 100 ug
EUR 164

Rabbit IgG F(ab')2-R-PE conjugate, isotype control

20009-FAb2-PE 100 tests
EUR 225

Rabbit IgG F(c)-biotin conjugate, isotype control

20009-Fc-B 100 ug
EUR 164

Rabbit IgG, purified (serum non-immune, isotype control), without azide, powder

20009-WA-1 1 mg
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Rabbit IgG, purified (serum non-immune, isotype control), without azide, powder

20009-WA-5 5 mg
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Human Insulin Antibody

20010-05011 150 ug
EUR 217

Human Insulin Antibody (Biotin Conjugate)

20010-05021 150 ug
EUR 276

Chicken IgG-Biotin conjugate (isotype control, non-immune), purified

20010-1-B 0.5 mg
EUR 225

Chicken IgM-Biotin conjugate (isotype control, non-immune) purified

20010-2-1-b 0.1 mg
EUR 225

Chicken IgG-Fc-Biotin conjugate (isotype control, non-immune), purified

20010-3-B 0.1 mg
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Human Synaptobrevin-2 Antibody

20011-05011 150 ug
EUR 217

Human Synaptobrevin-2 Antibody (Biotin Conjugate)

20011-05021 150 ug
EUR 276

Human Synaptobrevin-2 AssayLite Antibody (FITC Conjugate)

20011-05041 150 ug
EUR 428

Human Synaptobrevin-2 AssayLite Antibody (RPE Conjugate)

20011-05051 150 ug
EUR 428

Human Synaptobrevin-2 AssayLite Antibody (APC Conjugate)

20011-05061 150 ug
EUR 428

Human Synaptobrevin-2 AssayLite Antibody (PerCP Conjugate)

20011-05071 150 ug
EUR 471

Goat IgG FAB fragment-Biotin conjugate

20011-1-FAB-B 100 tests
EUR 225

Goat IgG F(ab')2 fragment, purified

20011-1-FAB2 1 mg
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Goat IgG-Agarose conjugate(aff matrix)

20011-AS-1 0.5 ml
EUR 164

Goat IgG (Whole, non-immune)-Biotin conjugate

20011-B 100 ug
EUR 164

Goat IgG F(ab')2 fragment-Biotin conjugate

20011-FAB2-B 100 tests
EUR 202

Goat IgG F(ab')2 fragment-Cy5 conjugate

20011-FAB2-Cy5 50 tests
EUR 202

Goat IgG F(ab')2 fragment-FITC conjugate

20011-FAB2-F 100 tests
EUR 202

Goat IgG FAB(ab')2 fragment-HRP conjugate

20011-FAB2-HP 100 tests
EUR 202

Goat IgG F(ab')2 fragment-R-PE conjugate

20011-FAB2-PE 50 tests
EUR 202

Goat IgG (fc)-Biotin conjugate (isotype control)

20011-Fc-B 100 ug
EUR 164


Conclusion: Expressions positive of placental alkaline phosphatase and octamer – bind transcription factor 3 / 4 can 2 marker dysgerminomas diagnosis. Surgery combined with radiotherapy and chemotherapy could improve the prognosis dysgerminomas. In addition, hormone replacement therapy with conjugated estrogens and medroxyprogesterone acetate greatly help to maintain female characteristics of patients with true hermaphroditism