Adult stem cells age during long-term culture in vitro, and neural stem cells (NSC), which can renew themselves and differentiate into neurons and glial cells, also in the show reduces the differentiation potential after repeated passaging. However, the mechanistic details underlying this process remains unclear.

In this study, we found that the long-term in vitro culture of NSCs resulted inflammatory- aging-associated upregulation and endoplasmic reticulum (ER) stress-related genes, including the proinflammatory cytokines interleukin (IL) 1β and IL6, which senescence- enzyme-linked matrix metallopeptidase 13 (MMP13), and ER stress-responsive transcription factor activating transcription factor 4 (ATF 4 ) and C / EBP homologous protein (CHOP).

However, the induction of cyclic and while the four reprogramming factor (POU domain, class 5, transcription factor 1, also known as octamer < / em> – bind transcription factor 4 ; SRY [sex determination region Y] -box 2; Kruppel – such as factor 4 , and myelocytomatosis oncogene; collectively referred to as OSKM) can inhibit the aging of the NSC, as indicated by a decrease in the expression of genes related to inflammation and ER stress.

We use ROSA- 4 F NSC, which revealed OSKM only one allele, to minimize the potential for full reprogramming or formation of tumors during NSC rejuvenation. We hope that this novel method of rejuvenation will increase the potential of NSCs as a clinical approach to the treatment of neurological diseases. True hermaphroditism with dysgerminomas: A case report ntroduction:

Inhibition of neural stem cell aging through the transient induction of reprogramming factors
Inhibition of neural stem cell aging through the transient induction of reprogramming factors

True hermaphroditism is a rare disorder and is usually sporadic.

It is defined by the presence of both ovaries and testes tissue together as ovotestis.Patient concerns: In this study, we report a rare case of true hermaphroditism with dysgerminomas. A 4 9 year old woman developed a mass in the inguinal region for 30 years. Recently three months, patients find that the size of the mass in her left inguinal region increased significantly.


Diagnosis: After surgical resection, the results of immunohistochemistry mass of the left reveals dysgerminomas with positive expression of placental alkaline phosphatase and octamer – bind transcription factor 3 / 4 , and the mass of the right is cryptorchidism a. chromosome analysis revealed a karyotype 4 6, XY. The combined immunohistochemistry and karyotype analysis, the diagnosis of true hermaphroditism with dysgerminomas made.


Intervention: Radiotherapy combined with chemotherapy after resection of the tumor used to improve his prognosis. Hormone replacement therapy with conjugated estrogens and medroxyprogesterone acetate is used to maintain her female characteristics.
Results: Patients undergoing hormone replacement and has been well over 6 months.

ETHYL VIOLET AZIDE BROTH

E05-105-500g 500 g
EUR 124

EUGONIC AGAR

E05-106-10kg 10 kg Ask for price

EUGONIC AGAR

E05-106-2Kg 2 Kg Ask for price

EUGONIC AGAR

E05-106-500g 500 g Ask for price

ENDO AGAR

E05-110-10kg 10 kg
EUR 2381

ENDO AGAR

E05-110-2Kg 2 Kg
EUR 557

ENDO AGAR

E05-110-500g 500 g
EUR 188

APT AGAR

A01-101-10kg 10 kg
EUR 1173

APT AGAR

A01-101-2Kg 2 Kg
EUR 294

APT AGAR

A01-101-500g 500 g
EUR 116

AGAR, BACTERIOLOGICAL

A01-102-10kg 10 kg
EUR 1684

AGAR, BACTERIOLOGICAL

A01-102-2kg 2kg
EUR 405

AGAR, BACTERIOLOGICAL

A01-102-500g 500 g
EUR 146

AGAR, HIGH GEL

A01-102IHG-10kg 10 kg
EUR 2219

AGAR, HIGH GEL

A01-102IHG-2Kg 2 Kg
EUR 521

AGAR, HIGH GEL

A01-102IHG-500g 500 g
EUR 178

AGAR,NOBLE

A01-102N-10kg 10 kg
EUR 3910

AGAR,NOBLE

A01-102N-2kg 2kg
EUR 889

AGAR,NOBLE

A01-102N-500g 500 g
EUR 278

ALT. THIOGLYCOLLATE MED.

A01-103-10kg 10 kg Ask for price

ALT. THIOGLYCOLLATE MED.

A01-103-2Kg 2 Kg Ask for price

ALT. THIOGLYCOLLATE MED.

A01-103-500g 500 g Ask for price

AMIES BROTH WITH CHARCOAL

A01-104-10kg 10 kg Ask for price

AMIES BROTH WITH CHARCOAL

A01-104-2kg 2kg Ask for price

AMIES BROTH WITH CHARCOAL

A01-104-500g 500 g Ask for price

AMIES BROTH W/O CHARCOAL

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AMIES BROTH W/O CHARCOAL

A01-105-2Kg 2 Kg Ask for price

AMIES BROTH W/O CHARCOAL

A01-105-500g 500 g Ask for price

AZIDE BLOOD AGAR BASE

A01-113-10kg 10 kg
EUR 2532

AZIDE BLOOD AGAR BASE

A01-113-2kg 2kg
EUR 589

AZIDE BLOOD AGAR BASE

A01-113-500g 500 g
EUR 197

AZIDE DEXTROSE BROTH

A01-114-10kg 10 kg
EUR 868

AZIDE DEXTROSE BROTH

A01-114-2Kg 2 Kg
EUR 228

AZIDE DEXTROSE BROTH

A01-114-500g 500 g
EUR 98

ANAEROBIC AGAR

A01-115-10kg 10 kg
EUR 2556

ANAEROBIC AGAR

A01-115-2kg 2kg
EUR 595

ANAEROBIC AGAR

A01-115-500g 500 g
EUR 198

A-1 MEDIUM

A01-116-10kg 10 kg
EUR 1034

A-1 MEDIUM

A01-116-2Kg 2 Kg
EUR 264

A-1 MEDIUM

A01-116-500g 500 g
EUR 108

AGAROSE 25G-125G -500G

A01-118-10kg 10 kg Ask for price

AGAROSE 25G-125G -500G

A01-118-2kg 2kg Ask for price

AGAROSE 25G-125G -500G

A01-118-500g 500 g
EUR 494

IL-2 Receptor ?, Human Recombinant

7100-10
EUR 196

IL-2 Receptor ?, Human Recombinant

7100-50
EUR 637

Human CellExp? IL-4 R?, Human Recombinant

7101-10
EUR 229

Human CellExp? IL-4 R?, Human Recombinant

7101-50
EUR 881

Human CellExp? IL-6 R?, Human Recombinant

7102-10
EUR 207

Human CellExp? IL-6 R?, Human Recombinant

7102-50
EUR 800

IL-9, Rat Recombinant

7103-10
EUR 278

IL-9, Rat Recombinant

7103-50
EUR 1132

IL-12p80, Human Recombinant

7104-10
EUR 392

IL-12p80, Human Recombinant

7104-50
EUR 1675

IL-17A, Mouse Recombinant

7105-10
EUR 196

IL-17A, Mouse Recombinant

7105-50
EUR 675

IL-17B, Human Recombinant

7106-10
EUR 196

IL-17B, Human Recombinant

7106-50
EUR 675

IL-17D, Human Recombinant

7107-10
EUR 196

IL-17D, Human Recombinant

7107-50
EUR 675

Human CellExp? IL-34, Human Recombinant

7108-10
EUR 278

Human CellExp? IL-34, Human Recombinant

7108-50
EUR 1132

IL-36RA, Human Recombinant

7109-10
EUR 196

IL-36RA, Human Recombinant

7109-50
EUR 675

IL-36?, Human Recombinant

7110-10
EUR 278

IL-36?, Human Recombinant

7110-50
EUR 1132

IL-36?, Human Recombinant

7111-10
EUR 278

IL-36?, Human Recombinant

7111-50
EUR 1132

Activin B, Human Recombinant

7112-10
EUR 479

Activin B, Human Recombinant

7112-50
EUR 2094

AITRL, Human Recombinant

7113-10
EUR 251

AITRL, Human Recombinant

7113-50
EUR 936

Amphiregulin, Human Recombinant

7114-10
EUR 147

Amphiregulin, Human Recombinant

7114-50
EUR 376

ANG-1, Human Recombinant

7115-10
EUR 251

ANG-1, Human Recombinant

7115-50
EUR 936

ANG-2, Human Recombinant

7116-10
EUR 251

ANG-2, Human Recombinant

7116-50
EUR 936

APRIL, Human Recombinant

7117-10
EUR 311

APRIL, Human Recombinant

7117-50
EUR 1300

APRIL, Mouse Recombinant

7118-10
EUR 196

APRIL, Mouse Recombinant

7118-50
EUR 675

Betacellulin, Murine Recombinant

7119-10
EUR 196

Betacellulin, Murine Recombinant

7119-50
EUR 675

Cardiotrophin-1, Murine Recombinant

7121-10
EUR 278

Cardiotrophin-1, Murine Recombinant

7121-50
EUR 1132

sCD100/Semaphorin-4D, Human Recombinant

7126-10
EUR 251

sCD100/Semaphorin-4D, Human Recombinant

7126-50
EUR 936

CTGFL/WISP-2, Human Recombinant

7129-10
EUR 234

CTGFL/WISP-2, Human Recombinant

7129-50
EUR 860

Human CellExp? DKK-1, Human Recombinant

7132-10
EUR 278

Human CellExp? DKK-1, Human Recombinant

7132-50
EUR 1132

Human CellExp? sDLL-1, Human Recombinant

7133-10
EUR 207

Human CellExp? sDLL-1, Human Recombinant

7133-50
EUR 675

Human CellExp? sDLL-4, Human Recombinant

7134-10
EUR 207

Human CellExp? sDLL-4, Human Recombinant

7134-50
EUR 675

Eotaxin-2/CCL24, murine recombinant

7137-10
EUR 207

Eotaxin-2/CCL24, murine recombinant

7137-50
EUR 675

Eotaxin-3/CCL26, human recombinant

7138-10
EUR 207

Eotaxin-3/CCL26, human recombinant

7138-50
EUR 675

Human CellExp? Fetuin A/ASHG, Human Recombinant

7142-10
EUR 153

Human CellExp? Fetuin A/ASHG, Human Recombinant

7142-50
EUR 381

Histone H3 Peptide, biotin conjugate

7143-01
EUR 240

Histone H3 Peptide, biotin conjugate

7143-1
EUR 1132

Histone H4 Peptide, tetra-acetylated, biotin conjugate

7144-01
EUR 240

Histone H4 Peptide, tetra-acetylated, biotin conjugate

7144-1
EUR 1132

FGF-5, human recombinant

7147-10
EUR 142

FGF-5, human recombinant

7147-50
EUR 359

FGF-6, human recombinant

7148-10
EUR 207

FGF-6, human recombinant

7148-50
EUR 675

FGF-16, human recombinant

7149-10
EUR 207

FGF-16, human recombinant

7149-50
EUR 675

FGF-17, human recombinant

7150-10
EUR 207

FGF-17, human recombinant

7150-50
EUR 675

FGF-23, human recombinant

7151-10
EUR 229

FGF-23, human recombinant

7151-50
EUR 860

GASP-1, human recombinant

7152-10
EUR 229

GASP-1, human recombinant

7152-50
EUR 833

GCP-2 (CXCL6), human recombinant

7153-10
EUR 207

GCP-2 (CXCL6), human recombinant

7153-50
EUR 675

BMP-9/GDF-2, human recombinant

7154-10
EUR 278

BMP-9/GDF-2, human recombinant

7154-50
EUR 1132

BMP-11/GDF-11, human recombinant

7155-10
EUR 240

BMP-11/GDF-11, human recombinant

7155-50
EUR 860

Gremlin-1, human recombinant

7159-10
EUR 142

Gremlin-1, human recombinant

7159-50
EUR 359

ICAM-1, human recombinant

7161-10
EUR 142

ICAM-1, human recombinant

7161-50
EUR 359

IFN-?1, human recombinant

7162-10
EUR 207

IFN-?1, human recombinant

7162-50
EUR 735

IFN-?2, human recombinant

7163-10
EUR 207

IFN-?2, human recombinant

7163-50
EUR 675

IGF-BP2, human recombinant

7165-10
EUR 251

IGF-BP2, human recombinant

7165-50
EUR 936

IGF-BP4, human recombinant

7166-10
EUR 251

IGF-BP4, human recombinant

7166-50
EUR 936

IGF-BP7, human recombinant

7167-10
EUR 207

IGF-BP7, human recombinant

7167-50
EUR 675

MCP-5/CCL12, murine recombinant

7168-10
EUR 207

MCP-5/CCL12, murine recombinant

7168-50
EUR 675

MIP-1?/CCL3, human recombinant

7173-10
EUR 207

MIP-1?/CCL3, human recombinant

7173-50
EUR 675

MIP-1?/CCL9/10, murine recombinant

7174-10
EUR 207

MIP-1?/CCL9/10, murine recombinant

7174-50
EUR 675

MIP-3/CCL23, human recombinant

7175-10
EUR 207

MIP-3/CCL23, human recombinant

7175-50
EUR 675

Nesfatin-1, human recombinant

7178-10
EUR 137

Nesfatin-1, human recombinant

7178-50
EUR 272

Human CellExp? PECAM-1, Human Recombinant

7184-10
EUR 153

Human CellExp? PECAM-1, Human Recombinant

7184-50
EUR 381

PF-4/CXCL4, murine recombinant

7187-10
EUR 207

PF-4/CXCL4, murine recombinant

7187-50
EUR 675

R-Spondin-1, human recombinant

7189-10
EUR 207

R-Spondin-1, human recombinant

7189-50
EUR 675

R-Spondin-2, human recombinant

7190-10
EUR 207

R-Spondin-2, human recombinant

7190-50
EUR 675

R-Spondin-3, human recombinant

7191-10
EUR 207

R-Spondin-3, human recombinant

7191-50
EUR 675

Relaxin-2, human recombinant

7194-10
EUR 207

Relaxin-2, human recombinant

7194-50
EUR 675

Relaxin-3, human recombinant

7195-10
EUR 207

Relaxin-3, human recombinant

7195-50
EUR 675

SDF-1?/CXCL2, rat recombinant

7199-10
EUR 207

SDF-1?/CXCL2, rat recombinant

7199-50
EUR 675

SDF-1?/CXCL2, rat recombinant

7200-10
EUR 207

SDF-1?/CXCL2, rat recombinant

7200-50
EUR 675

Semaphorin 3A, human recombinant

7201-10
EUR 207

Semaphorin 3A, human recombinant

7201-50
EUR 675

sTRAIL Receptor-1/DR4, human recombinant

7206-10
EUR 153

sTRAIL Receptor-1/DR4, human recombinant

7206-50
EUR 381

VAP-1, human recombinant

7210-10
EUR 321

VAP-1, human recombinant

7210-50
EUR 1186

Human CellExp? VCAM-1, Human Recombinant

7211-10
EUR 142

Human CellExp? VCAM-1, Human Recombinant

7211-50
EUR 381

TAFA-2, human recombinant

7213-10
EUR 207

TAFA-2, human recombinant

7213-50
EUR 675

Thymosin-?4, human recombinant

7216-10
EUR 131

Thymosin-?4, human recombinant

7216-50
EUR 272

TL-1A, human recombinant

7219-10
EUR 207


Conclusion: Expressions positive of placental alkaline phosphatase and octamer – bind transcription factor 3 / 4 can 2 marker dysgerminomas diagnosis. Surgery combined with radiotherapy and chemotherapy could improve the prognosis dysgerminomas. In addition, hormone replacement therapy with conjugated estrogens and medroxyprogesterone acetate greatly help to maintain female characteristics of patients with true hermaphroditism