Induced pluripotent stem (iPS) cells are laboratory-produced cells that combine the advantages of biological and adult somatic stem cells for cell-based therapies. The reprogramming of cells, such as fibroblasts, into embryonic stem cell-like state is done by ectopic expression of transcription factor is responsible for generating embryonic stem cell properties.

This primer factor is octamer – bind transcription factor 4 (Oct3 / 4 ), sex determining region Y-box 2 (Sox2), Krüppel like factor 4 (Klf 4 ), and the proto-oncogene homolog protein from bird myelocytomatosis (c-Myc). Somatic cells can be easily obtained from the patient to be subjected to cell therapy and reprogrammed to obtain necessary high plasticity of embryonic stem cells.

These cells have no ethical limitations were involved, as in the case of embryonic stem cells, and displays minimal risk of immunologic rejection after transplantation. Currently, several ongoing clinical trials, most of them in Phase I or II. However, some of the inherent risks, such as chromosomal instability, insertional tumor, and teratoma formation, must be overcome to achieve full clinical translation. However, clinical trials and extensive basic research studying the biology of these cells, a promising future for the human cell-based therapy using iPS cells seem to be more clear and close.

Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies
Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies

Dexamethasone inhibits stemness Improving maintenance and chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation HIF-1α and Oct4

It has been controversial whether patients with hepatocellular carcinoma (HCC) should receive glucocorticoid therapy during chemotherapy. Recent studies have shown that glucocorticoids increase the sensitivity of tumor therapy for some chemotherapy drugs, but the specific mechanism remains unclear. In this study, dexamethasone (Dex) is used for stem cells to treat HCC. The results showed that Dex reduced maintenance stemness and self-renewal of cells HCC stem, promoted the epithelial-to-mesenchymal transition, migration inhibiting and angiogenesis and, more importantly, increase the sensitivity of cells to herpes simplex virus thymidine kinase / ganciclovir system of medicine in vitro and in vivo.

Further mechanistic analysis showed that Dex inhibits small ubiquitin-like modifier (SUMO) modification of some proteins in HCC stem cells, including hypoxia inducible factor (HIF) -1α, protein hypoxia tolerance is important, and octamer – bind transcription factor 4 (October 4 ), stemness protein essential maintenance. DeSUMOylation encourage HIF-1α and October 4 reduced their accumulation in the nucleus, thereby inhibiting tumor angiogenesis and maintenance of stemness.

This finding provides a new perspective to study the mechanisms underlying the effects of anti-hepatocarcinogenesis of Dex. Because of the side effects of glucocorticoids on low-dose anti-inflammatory effect, the right combination of glucocorticoids and chemotherapy drugs are expected to improve the survival of HCC patients and their prognosis.Androgen deprivation therapy eventually lead to the development castration- resistant prostate cancer (CRPC)

Hamster IgG, purified (Armenian, Isotype control)
20003-1AH 1 mg
EUR 263
G. Pig IgG Fc-Biotin conjugate (isotype control, non-immune) purified
20004-3-B 0.1 mg
EUR 225
G. Pig IgG-Biotin conjugate (isotype control)
20004-B 100 ug
EUR 202
Rat IgG F(ab')2 fragment, purified (isotype control)
20005-1-FAB2 1 mg
EUR 202
Rat IgG (Fc)-Biotin Conjuagte (isotype control), purified
20005-1-FC-B 0.1 mg
EUR 225
Rat IgG1-Biotin conjugate (isotype control)
20005-11-B 100 ug
EUR 202
Rat IgG2a-APC conjugate (isotype control)
20005-12-APC 25 tests
EUR 202
Rat IgG2a-Biotin conjugate (isotype control)
20005-12-B 100 ug
EUR 202
Rat IgG2b-Biotin conjugate (isotype control)
20005-13-B 100 ug
EUR 202
Rat IgG2c-Biotin conjugate (isotype control)
20005-14-B 100 ug
EUR 225
Rat IgM-Biotin conjugate (isotype control)
20005-21-B 100 ug
EUR 225
Rat IgG-Agarose conjugate(aff matrix)
20005-AS-1 0.5 ml
EUR 164
Rat IgG-Biotin conjugate (isotype control) (Isotype control)
20005-B 100 ug
EUR 164
Sheep IgG-Biotin Conjugate (isotype control, non-immune), purified
20006-1-B 0.5 mg
EUR 202
Sheep IgM-Biotin Conjugate (non-immune) control, purified
20006-2-B 0.1 mg
EUR 225
Sheep IgG Fc-Biotin Conjugate (isotype control, non-immune), purified
20006-4-B 0.5 mg
EUR 202
Human IgG-Biotin conjugate (isotype control, non-immune), purified
20007-1-B 0.5 mg
EUR 225
Human IgG (>98%, non-immune, control, Liquid @ 10 mg/ml, azide free, bulk size)
20007-1-BL-1 10 ml Ask for price
Human IgG (>98%, non-immune, control, powder, azide free, bulk size)
20007-1-BP-1 1 g
EUR 651
Human IgG (>98%, non-immune, control, powder, azide free, bulk size)
20007-1-BP-10 10 g
EUR 4313
Human IgG Fab fragment-Biotin Conjugate, purified
20007-1-FAB-B 0.1 mg
EUR 202
Human IgG F(ab')2 fragment, purified
20007-1-FAB2 1 mg
EUR 202
Human IgG Fab2 fragment-Biotin Conjugate, purified
20007-1-FAB2-B 0.1 mg
EUR 202
Human IgG Fc-Biotin conjugate (isotype control, non-immune), purified
20007-1-Fc-B 0.1 mg
EUR 164
Human IgG (Fc) fragment, purified (>95%, low endotoxin)
20007-1-FC-LE 100 ul
EUR 225
Human IgG (Fc) fragment-Biotin purified (>95%, low endotoxin)
20007-1-FC-LE-B 25 ug
EUR 286
Human IgG (serum origin, purified >97%, low endotoxin, azide free)
20007-1-LE-1 1 mg
EUR 164
Human IgG-Biotin (serum origin, purified >97%, low endotoxin, azide free)
20007-1-LE-BTN 100 ug
EUR 286
TruStrip RDT Human IgG Rapid test cards, 10/pk
20007-1-RDT 1 Pk
EUR 171
TruStrip RDT Human IgG Rapid test cards, 25/pk
20007-1-RDT-25 1 Pk
EUR 293
Human IgM, purified (native, isotype control, >96% pure, ELISA Grade)
20007-2 1 mg
EUR 164
Human IgM purified (isotype control, >96% pure, ELISA Grade)
20007-2-10 10 mg
EUR 895
Human IgM purified (isotype control, >96% pure, ELISA Grade)
20007-2-5 5 mg
EUR 529
Human IgM (myeloma, >96%, non-immune, control; bulk size)
20007-2-B-100 100 mg Ask for price
Human IgM (myeloma, >96%, non-immune, control; bulk size)
20007-2-B-1000 1000 mg Ask for price
Human IgM-Biotin conjugate (myeloma, isotype control)
20007-2-MB 100 ug
EUR 164
Human IgM (Rheumatoid Factor plasma, >40,000 IU/ml, purifed for ELISA)
20007-2-RF 100 ul
EUR 469
Human IgE (myeloma, kappa), purified (isotype control, >95%, low endotoxin, azide free)
20007-3-LE-50 100 ug
EUR 408
Human IgE-Biotin (myeloma, kappa), purified (isotype control, >95%, low endotoxin, azide free)
20007-3-LE-BTN 100 ul
EUR 408
Human IgM Fab mu fragment (myeloma)-Biotin conjugate (isotype control)
20007-4-B 100 ug
EUR 225
Human IgG-Fc fragment (97%, low endotoxin, azide free)
20007-F-LE-100 100 ug
EUR 164
Human IgG-Fc fragment-Biotin (97%, low endotoxin, azide free)
20007-F-LE-BTN 100 ug
EUR 286
Human IgG1-Biotin Conjugate (-ve control)
20007-G1-B 100 ug
EUR 164
Recombinant (HEK) Human IgG1 Fc (103Cys/Ser, 99-330aa, His-tag, >95%, low endotoxin)
20007-G1-FC 50 ug
EUR 286
Human IgG2-Biotin Conjugate
20007-G2-B 100 ug
EUR 164
Recombinant (HEK) Human IgG2-Fc (257Ser/Ala, 99-327aa, His-tag, >95%, low endotoxin)
20007-G2-FC 50 ug
EUR 286
Human IgG3-Biotin Conjugate
20007-G3-B 100 ug
EUR 164
Recombinant (HEK) Human IgG3-Fc (99-377aa, His-tag, >95%, low endotoxin)
20007-G3-FC 50 ug
EUR 286
Human IgG4-Biotin Conjugate
20007-G4-B 100 ug
EUR 164
Recombinant (HEK) Human IgG4-Fc (108Ser/Pro, 99-327aa, His-tag, >95%, low endotoxin)
20007-G4-FC 50 ug
EUR 286
Mouse IgG F(ab')2 fragment, purified
20008-1-Fab2 1 mg
EUR 202
Mouse IgG (>97%, ELISA/RIA/Diagnostic Grade; -ve mouse viruses & Protein A/G free)
20008-1-WA 1 mg
EUR 164
Mouse IgG-Agarose conjugate (aff matrix)
20008-AS-1 0.5 ml
EUR 164
Mouse IgG-Biotin conjugate (isotype control)
20008-B 50 Tests
EUR 164
Mouse IgG-Biotin conjugate (isotype control)
20008-BT-1 1 mg
EUR 164
Mouse IgG Fab-Biotin conjugate (isotype control)
20008-Fab-B 100 ug
EUR 164
Mouse IgG F(ab')2-Biotin conjugate (isotype control)
20008-Fab2-B 100 ug
EUR 164
Mouse IgG F(ab')2-FITC conjugate (isotype control)
20008-Fab2-F 100 ug
EUR 164
Mouse IgG F(ab')2-HRP conjugate (isotype control)
20008-Fab2-HP 100 ug
EUR 164
Mouse IgG F(c)-Biotin conjugate (isotype control)
20008-Fc-B 100 ug
EUR 164
Rabbit IgG Fab-Biotin Conjugate, purified
20009-1-FAB-B 0.1 mg
EUR 202
Rabbit IgG F(ab')2 fragment, purified
20009-1-FAB2 1 mg
EUR 202
Recombinant (HEK) Rabbit IgG (Fc) (101-323aa, 185Thr/Asn284Ser, ~33 kda, >95%, Low Endotoxin)
20009-1-R-FC 50 ug
EUR 286
Rabbit IgM-Biotin Conjugate (isotype control, non-immune), purified
20009-2-1-B 0.1 mg
EUR 225
Rabbit IgA-Biotin Conjugate (isotype control, non-immune), purified
20009-3-1-B 0.1 mg
EUR 408
Rabbit IgG-Agarose conjugate
20009-AS-1 0.5 ml
EUR 164
Rabbit IgG (Whole, non-immune)-Biotin conjugate
20009-B 100 ug
EUR 164
Rabbit IgG-biotinylated (isotype control)
20009-BT-1 1 mg
EUR 286
Rabbit IgG F(ab')2-biotin conjugate, isotype control
20009-FAb2-B 100 ug
EUR 164
Rabbit IgG F(ab')2-FITC conjugate, isotype control
20009-FAb2-F 100 ug
EUR 164
Rabbit IgG F(ab')2-HRP conjugate, isotype control
20009-FAb2-HP 100 ug
EUR 164
Rabbit IgG F(ab')2-R-PE conjugate, isotype control
20009-FAb2-PE 100 tests
EUR 225
Rabbit IgG F(c)-biotin conjugate, isotype control
20009-Fc-B 100 ug
EUR 164
Rabbit IgG, purified (serum non-immune, isotype control), without azide, powder
20009-WA-1 1 mg
EUR 141
Rabbit IgG, purified (serum non-immune, isotype control), without azide, powder
20009-WA-5 5 mg
EUR 286
Human Insulin Antibody
20010-05011 150 ug
EUR 217
Human Insulin Antibody (Biotin Conjugate)
20010-05021 150 ug
EUR 276
Chicken IgG-Biotin conjugate (isotype control, non-immune), purified
20010-1-B 0.5 mg
EUR 225
Chicken IgM-Biotin conjugate (isotype control, non-immune) purified
20010-2-1-b 0.1 mg
EUR 225
Chicken IgG-Fc-Biotin conjugate (isotype control, non-immune), purified
20010-3-B 0.1 mg
EUR 225
Human Synaptobrevin-2 Antibody
20011-05011 150 ug
EUR 217
Human Synaptobrevin-2 Antibody (Biotin Conjugate)
20011-05021 150 ug
EUR 276
Human Synaptobrevin-2 AssayLite Antibody (FITC Conjugate)
20011-05041 150 ug
EUR 428
Human Synaptobrevin-2 AssayLite Antibody (RPE Conjugate)
20011-05051 150 ug
EUR 428
Human Synaptobrevin-2 AssayLite Antibody (APC Conjugate)
20011-05061 150 ug
EUR 428
Human Synaptobrevin-2 AssayLite Antibody (PerCP Conjugate)
20011-05071 150 ug
EUR 471
Goat IgG FAB fragment-Biotin conjugate
20011-1-FAB-B 100 tests
EUR 225
Goat IgG F(ab')2 fragment, purified
20011-1-FAB2 1 mg
EUR 164
Goat IgG-Agarose conjugate(aff matrix)
20011-AS-1 0.5 ml
EUR 164
Goat IgG (Whole, non-immune)-Biotin conjugate
20011-B 100 ug
EUR 164
Goat IgG F(ab')2 fragment-Biotin conjugate
20011-FAB2-B 100 tests
EUR 202
Goat IgG F(ab')2 fragment-Cy5 conjugate
20011-FAB2-Cy5 50 tests
EUR 202
Goat IgG F(ab')2 fragment-FITC conjugate
20011-FAB2-F 100 tests
EUR 202
Goat IgG FAB(ab')2 fragment-HRP conjugate
20011-FAB2-HP 100 tests
EUR 202
Goat IgG F(ab')2 fragment-R-PE conjugate
20011-FAB2-PE 50 tests
EUR 202
Goat IgG (fc)-Biotin conjugate (isotype control)
20011-Fc-B 100 ug
EUR 164
E. coli GroEL Antibody
20012-05011 150 ug
EUR 217
E. coli GroEL Antibody (Biotin Conjugate)
20012-05021 150 ug
EUR 276
E. coli GroEL AssayLite Antibody (FITC Conjugate)
20012-05041 150 ug
EUR 428
E. coli GroEL AssayLite Antibody (RPE Conjugate)
20012-05051 150 ug
EUR 428
E. coli GroEL AssayLite Antibody (APC Conjugate)
20012-05061 150 ug
EUR 428
E. coli GroEL AssayLite Antibody (PerCP Conjugate)
20012-05071 150 ug
EUR 471
Monkey IgG (Rhesus, Whole, non-immune)-Biotin conjugate
20012-B 100 ug
EUR 202
Chimpanzee IgG (non-immune)-Biotin conjugate
20012-Ch-B 100 ug
EUR 286
CF488A F(ab')2 fragment of goat anti-rabbit IgG(H+L), 2 mg/mL
20013 0.25 mL
EUR 190
Description: Minimum order quantity: 1 unit of 0.25 mL
Human Interferon-gamma (IFN-gamma) Antibody
20013-05011 150 ug
EUR 217
Human Interferon-gamma (IFN-gamma) Antibody (Biotin Conjugate)
20013-05021 150 ug
EUR 276
Human Interferon-gamma (IFN-gamma) AssayLite Antibody (FITC Conjugate)
20013-05041 150 ug
EUR 428
Human Interferon-gamma (IFN-gamma) AssayLite Antibody (RPE Conjugate)
20013-05051 150 ug
EUR 428
Human Interferon-gamma (IFN-gamma) AssayLite Antibody (APC Conjugate)
20013-05061 150 ug
EUR 428
Human Interferon-gamma (IFN-gamma) AssayLite Antibody (PerCP Conjugate)
20013-05071 150 ug
EUR 471
Monkey Serum IgM-biotin conjugate (Rhesus, non-immune, isotype control), purified
20013-1-B 25 ug
EUR 225
Annexin V, Recombinant
20014 100 ug
EUR 219
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200
Annexin V, Recombinant
20015 1 mg
EUR 702
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200
Donkey IgG-Biotin conjugate (non-immune, isotype control) purified
20015-1-B 0.5 mg
EUR 225
Donkey IgM-Biotin conjugate (unlabeled, non-immune, isotype control) purified
20015-2-1-B 0.1 mg
EUR 225
Donkey IgG (Whole, non-immune)-Biotin conjugate
20015-B 100 ug
EUR 164
Dog IgG-Biotin Conjugate (isotype control, non-immune), purified
20016-1-B 0.1 mg
EUR 225
Dog IgG F(ab')2 fragment (isotype control, non-immune) purified
20016-1-FAB2 1 mg
EUR 164
Dog IgG Fc-Biotin Conjugate (isotype control, non-immune), purified
20016-FC-B 0.1 mg
EUR 225
Pig IgG-Biotin conjugate (swine non-immune, isotype control), purified
20017-1-B 0.1 mg
EUR 263
Pig IgM-Biotin (swine non-immune, isotype control), purified
20017-2-1-B 0.1 mg
EUR 263
Pig IgG Fc-Biotin conjugate (swine non-immune, isotype control), purified
20017-3-B 0.1 mg
EUR 263
Monkey Serum IgM-biotin conjugate (Cyno., non-immune, isotype control), purified
20018-1-B 100 ug
EUR 263
Monkey IgG (Cynomolgous, non-immune)-Biotin conjugate
20018-B 100 ug
EUR 202
Goat Anti-Rabbit IgA (alpha chain) unlabeled, aff pure
20019 0.5 mg
EUR 202
Horse IgM (Equine, Whole IgM, control, non-immune)-biotinylated, purified
20019-2-B 100 ug
EUR 202
Horse IgG (Equine, Whole IgG, control, non-immune)-biotinylated, purified
20019-B 0.5 mg
EUR 164
Bison IgG, semi-pure for ELISA (Control, non-immune, isotype control)
20025-1 100 ug
EUR 225
Goat Anti-Rabbit IgA (alpha chain)-HRP conjugate
20029 0.5 ml
EUR 263
Annexin V, FITC Labeled
20030 100 tests
EUR 219
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200
TruStrip RDT Llama IgG Rapid test cards, 10/pk
20030-RDT-10 1 Pk
EUR 171
TruStrip RDT Llama IgG Rapid test cards, 25/pk
20030-RDT-25 1 Pk
EUR 293
Alpaca IgG (Control, non-immune, isotype control, ELISA grade)
20032-1 1 mg
EUR 164
CF555 goat anti-rabbit IgG(H+L), 2mg/mL
20033-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF555 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed, 2 mg/mL
20034-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
CF555 F(ab')2 fragment of goat anti-rabbit IgG(H+L), 2 mg/mL
20035 0.25 mL
EUR 190
Description: Minimum order quantity: 1 unit of 0.25 mL
CF555 F(ab')2 fragment of goat anti-rabbit IgG(H+L), 2 mg/mL
20035-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
CF555 goat anti-guinea pig IgG(H+L), 2 mg/mL
20036-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF555 donkey anti-mouse IgG(H+L), highly cross-adsorbed, 2 mg/mL
20037-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
CF555 donkey anti-rabbit IgG(H+L), highly cross-adsorbed, 2 mg/mL
20038-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
CF555 donkey anti-goat IgG(H+L), highly cross-adsorbed, 2 mg/mL
20039-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
DABCYL succinimidyl ester [4-((4-(Dimethylamino)phenyl)azo)benzoic acid, succinimidyl ester] *CAS 146998-31-4*
2004 1 g
EUR 350
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200
CF647 goat anti-mouse IgG(H+L), 2mg/mL
20040-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF647 goat anti-guinea pig IgG(H+L), 2 mg/mL
20041-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF647 F(ab')2 fragment of goat anti-mouse IgG(H+L), 2 mg/mL
20042-1 50ul
EUR 137
Description: Minimum order quantity: 1 unit of 50ul
CF647 goat anti-rabbit IgG(H+L), 2mg/mL
20043-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
CF647 goat anti-chicken IgY (IgG) (H+L), highly cross-adsorbed, 2 mg/mL
20044-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
CF647 F(ab')2 fragment of goat anti-rabbit IgG(H+L), 2 mg/mL
20045 0.25mL
EUR 190
Description: Minimum order quantity: 1 unit of 0.25mL
CF647 F(ab')2 fragment of goat anti-rabbit IgG(H+L), 2 mg/mL
20045-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
CF647 donkey anti-mouse IgG(H+L), highly cross-adsorbed, 2 mg/mL
20046-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
CF647 donkey anti-rabbit IgG(H+L), highly cross-adsorbed, 2mg/mL
20047-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
CF647 donkey anti-goat IgG(H+L), highly cross-adsorbed, 2 mg/mL
20048-1 50uL
EUR 137
Description: Minimum order quantity: 1 unit of 50uL
CF647 rabbit anti-goat IgG(H+L), 2 mg/mL
20049-1 50uL
EUR 120
Description: Minimum order quantity: 1 unit of 50uL
DABCYL succinimidyl ester [4-((4-(Dimethylamino)phenyl)azo)benzoic acid, succinimidyl ester] *CAS 146998-31-4*
2005 5 g
EUR 1311
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200
Pluronic® F-127 *Cell culture tested *
20050 10 g
EUR 115
  • R-phrase: R20, R21, R22
  • H-Phrase: H303, H313, H333
  • Symbol for dangerous compounds: Xn
  • UNSPEC Code: 12352200

Here, we demonstrate for the first time that histone H3K 4 SETD1A methyltransferase is the main regulator of the proliferation of metastatic CRPC (mCRPC). SETD1A expression was significantly correlated with survival rate of patients with prostate cancer.