Induced pluripotent stem (iPS) cells are laboratory-produced cells that combine the advantages of biological and adult somatic stem cells for cell-based therapies. The reprogramming of cells, such as fibroblasts, into embryonic stem cell-like state is done by ectopic expression of transcription factor is responsible for generating embryonic stem cell properties.

This primer factor is octamer – bind transcription factor 4 (Oct3 / 4 ), sex determining region Y-box 2 (Sox2), Krüppel like factor 4 (Klf 4 ), and the proto-oncogene homolog protein from bird myelocytomatosis (c-Myc). Somatic cells can be easily obtained from the patient to be subjected to cell therapy and reprogrammed to obtain necessary high plasticity of embryonic stem cells.

These cells have no ethical limitations were involved, as in the case of embryonic stem cells, and displays minimal risk of immunologic rejection after transplantation. Currently, several ongoing clinical trials, most of them in Phase I or II. However, some of the inherent risks, such as chromosomal instability, insertional tumor, and teratoma formation, must be overcome to achieve full clinical translation. However, clinical trials and extensive basic research studying the biology of these cells, a promising future for the human cell-based therapy using iPS cells seem to be more clear and close.

Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies
Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies

Dexamethasone inhibits stemness Improving maintenance and chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation HIF-1α and Oct4

It has been controversial whether patients with hepatocellular carcinoma (HCC) should receive glucocorticoid therapy during chemotherapy. Recent studies have shown that glucocorticoids increase the sensitivity of tumor therapy for some chemotherapy drugs, but the specific mechanism remains unclear. In this study, dexamethasone (Dex) is used for stem cells to treat HCC. The results showed that Dex reduced maintenance stemness and self-renewal of cells HCC stem, promoted the epithelial-to-mesenchymal transition, migration inhibiting and angiogenesis and, more importantly, increase the sensitivity of cells to herpes simplex virus thymidine kinase / ganciclovir system of medicine in vitro and in vivo.

Further mechanistic analysis showed that Dex inhibits small ubiquitin-like modifier (SUMO) modification of some proteins in HCC stem cells, including hypoxia inducible factor (HIF) -1α, protein hypoxia tolerance is important, and octamer – bind transcription factor 4 (October 4 ), stemness protein essential maintenance. DeSUMOylation encourage HIF-1α and October 4 reduced their accumulation in the nucleus, thereby inhibiting tumor angiogenesis and maintenance of stemness.

This finding provides a new perspective to study the mechanisms underlying the effects of anti-hepatocarcinogenesis of Dex. Because of the side effects of glucocorticoids on low-dose anti-inflammatory effect, the right combination of glucocorticoids and chemotherapy drugs are expected to improve the survival of HCC patients and their prognosis.Androgen deprivation therapy eventually lead to the development castration- resistant prostate cancer (CRPC)

LIN7A Antibody, Biotin conjugated

1-CSB-PA012963LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LIN7A. Recognizes LIN7A from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

LIN28 antibody

10R-10733 100 ug
EUR 457.2
Description: Mouse monoclonal LIN28 antibody

LIN28 antibody

10R-2014 100 ul
EUR 522
Description: Mouse monoclonal LIN28 antibody

Lin28 antibody

20R-2501 50 ug
EUR 337.2
Description: Rabbit polyclonal Lin28 antibody

Lin28 Antibody

25055-100ul 100ul
EUR 468

Lin28 Antibody

21426-100ul 100ul
EUR 302.4

Lin28 Antibody

21426-50ul 50ul
EUR 224.4

Lin28 antibody

3091-200 each
EUR 379.2

Lin28 antibody

3091-30T each
EUR 175.2

LIN28 Antibody

BF0638 200ul
EUR 540

Lin28 antibody

70R-11606 200 ug
EUR 483.6
Description: Rabbit polyclonal Lin28 antibody

Lin28 Antibody

5605-002mg 0.02 mg
EUR 206.18
Description: Lin28 Antibody: Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

Lin28 Antibody

5605-01mg 0.1 mg
EUR 523.7
Description: Lin28 Antibody: Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

Lin28 Antibody

49538-100ul 100ul
EUR 399.6

Lin28 Antibody

49538-50ul 50ul
EUR 286.8

LIN28 antibody

70R-18278 50 ul
EUR 522
Description: Rabbit polyclonal LIN28 antibody

LIN28 Antibody

F41528-0.08ML 0.08 ml
EUR 140.25
Description: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

LIN28 Antibody

F41528-0.4ML 0.4 ml
EUR 322.15
Description: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

LINC00846 Antibody (Biotin)

20-abx311645
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

LINC00299 Antibody (Biotin)

20-abx314553
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

LINC01553 Antibody (Biotin)

20-abx303235
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Lin-28 Homolog B (LIN28B) Antibody (Biotin)

20-abx315063
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Lin-28 Homolog A (LIN28A) Antibody (Biotin)

20-abx337281
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human LIN7C Antibody (Biotin Conjugate)

33386-05121 150 ug
EUR 442.8

LIN37 Polyclonal Antibody, Biotin Conjugated

A59631
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Anti-B19 Antibody BIOTIN

STJ501375 100 µg
EUR 703.2

Anti-MB Antibody (Biotin)

STJ501832 100 µg
EUR 703.2

Anti-Brk Antibody BIOTIN

STJ502712 100 µg
EUR 703.2

Anti-BLK Antibody (Biotin)

STJ500259 100 µg
EUR 703.2

Anti-BTK Antibody (Biotin)

STJ500304 100 µg
EUR 703.2

LIN7A Polyclonal Antibody, Biotin Conjugated

A62877
  • EUR 684.66
  • EUR 302.50
  • EUR 423.50
  • 100 µg
  • 50 ul
  • 100 ul

Anti-PGR Antibody (Biotin)

STJ502476 100 µg
EUR 703.2

Anti-PGR Antibody (Biotin)

STJ502478 100 µg
EUR 703.2

Anti-PRL Antibody (Biotin)

STJ502656 100 µg
EUR 703.2

Anti-PRL Antibody (Biotin)

STJ502658 100 µg
EUR 703.2

Anti-VHL Antibody (Biotin)

STJ502736 100 µg
EUR 703.2

Anti-SFN Antibody (Biotin)

STJ502961 100 µg
EUR 703.2

Anti-SHC Antibody BIOTIN

STJ503000 100 µg
EUR 703.2

Anti-SYK Antibody (Biotin)

STJ503183 100 µg
EUR 703.2

Anti-SYP Antibody (Biotin)

STJ503187 100 µg
EUR 703.2

Anti-SYP Antibody (Biotin)

STJ503189 100 µg
EUR 703.2

Anti-SRC Antibody (Biotin)

STJ503202 100 µg
EUR 703.2

Anti-SRC Antibody (Biotin)

STJ503204 100 µg
EUR 703.2

Anti-TEK Antibody (Biotin)

STJ503259 100 µg
EUR 703.2

Anti-TEK Antibody (Biotin)

STJ503261 100 µg
EUR 703.2

Anti-trp Antibody BIOTIN

STJ503409 100 µg
EUR 703.2

Anti-AFP Antibody (Biotin)

STJ500052 100 µg
EUR 703.2

Anti-AGE Antibody BIOTIN

STJ500055 100 µg
EUR 703.2

Anti-AQR Antibody (Biotin)

STJ500151 100 µg
EUR 703.2

Anti-Axl Antibody BIOTIN

STJ500199 100 µg
EUR 703.2

Anti-C4A Antibody (Biotin)

STJ500328 100 µg
EUR 703.2

Anti-CD2 Antibody (Biotin)

STJ500437 100 µg
EUR 703.2

Anti-CD2 Antibody (Biotin)

STJ500439 100 µg
EUR 703.2

Anti-CR2 Antibody (Biotin)

STJ500443 100 µg
EUR 703.2

Anti-CR2 Antibody (Biotin)

STJ500445 100 µg
EUR 703.2

Anti-CD4 Antibody (Biotin)

STJ500470 100 µg
EUR 703.2

Anti-CD4 Antibody (Biotin)

STJ500472 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500565 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500568 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500570 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500572 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500574 100 µg
EUR 703.2

Anti-MYC Antibody (Biotin)

STJ500593 100 µg
EUR 703.2

Anti-MYC Antibody (Biotin)

STJ500595 100 µg
EUR 703.2

Anti-DCC Antibody (Biotin)

STJ500739 100 µg
EUR 703.2

Anti-DCK Antibody BIOTIN

STJ500742 100 µg
EUR 703.2

Anti-DEK Antibody (Biotin)

STJ500751 100 µg
EUR 703.2

Anti-ERG Antibody (Biotin)

STJ500950 100 µg
EUR 703.2

Anti-ERG Antibody (Biotin)

STJ500952 100 µg
EUR 703.2

Anti-FGR Antibody (Biotin)

STJ501047 100 µg
EUR 703.2

Anti-FSH Antibody BIOTIN

STJ501089 100 µg
EUR 703.2

Anti-FYN Antibody (Biotin)

STJ501110 100 µg
EUR 703.2

Anti-GFP Antibody BIOTIN

STJ501149 100 µg
EUR 703.2

Anti-GBA Antibody (Biotin)

STJ501179 100 µg
EUR 703.2

Anti-LTF Antibody (Biotin)

STJ501354 100 µg
EUR 703.2

Anti-LTF Antibody (Biotin)

STJ501356 100 µg
EUR 703.2

Anti-ILK Antibody (Biotin)

STJ501450 100 µg
EUR 703.2

Anti-ITK Antibody (Biotin)

STJ501510 100 µg
EUR 703.2

Anti-LCT Antibody BIOTIN

STJ501565 100 µg
EUR 703.2

Anti-LAT Antibody (Biotin)

STJ501580 100 µg
EUR 703.2

Anti-LCK Antibody (Biotin)

STJ501586 100 µg
EUR 703.2

Anti-LYN Antibody (Biotin)

STJ501640 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501782 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501784 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501786 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501788 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501790 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501901 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501903 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501905 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501907 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501909 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501911 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501913 100 µg
EUR 703.2

Anti-OGT Antibody (Biotin)

STJ502000 100 µg
EUR 703.2

Anti-BCL6 Antibody (Biotin)

STJ500221 100 µg
EUR 703.2

Anti-BCL6 Antibody (Biotin)

STJ500224 100 µg
EUR 703.2

Anti-BCL6 Antibody (Biotin)

STJ500227 100 µg
EUR 703.2

Anti-BCL6 Antibody (Biotin)

STJ500229 100 µg
EUR 703.2

Anti-BMP1 Antibody (Biotin)

STJ500266 100 µg
EUR 703.2

Anti-BMP1 Antibody (Biotin)

STJ500268 100 µg
EUR 703.2

Anti-BMP2 Antibody BIOTIN

STJ500273 100 µg
EUR 703.2

Anti-BMP4 Antibody BIOTIN

STJ500275 100 µg
EUR 703.2

Anti-BRAF Antibody (Biotin)

STJ500283 100 µg
EUR 703.2

Anti-BST1 Antibody (Biotin)

STJ500286 100 µg
EUR 703.2

Anti-BST2 Antibody (Biotin)

STJ500291 100 µg
EUR 703.2

Anti-BST2 Antibody (Biotin)

STJ500293 100 µg
EUR 703.2

Anti-BST2 Antibody (Biotin)

STJ500295 100 µg
EUR 703.2

Anti-5HT1A Antibody BIOTIN

STJ500001 100 µg
EUR 703.2

Anti-5HT1B Antibody BIOTIN

STJ500004 100 µg
EUR 703.2

Anti-PAX5 Antibody (Biotin)

STJ502158 100 µg
EUR 703.2

Anti-PAX5 Antibody (Biotin)

STJ502160 100 µg
EUR 703.2

Anti-PAX5 Antibody (Biotin)

STJ502162 100 µg
EUR 703.2

Anti-PAX8 Antibody BIOTIN

STJ502167 100 µg
EUR 703.2

Anti-PAX8 Antibody BIOTIN

STJ502169 100 µg
EUR 703.2

Anti-PAX8 Antibody BIOTIN

STJ502171 100 µg
EUR 703.2

Anti-NPPB Antibody (Biotin)

STJ502174 100 µg
EUR 703.2

Anti-PDE4 Antibody BIOTIN

STJ502277 100 µg
EUR 703.2

Anti-PDPN Antibody (Biotin)

STJ502407 100 µg
EUR 703.2

Anti-PDPN Antibody (Biotin)

STJ502409 100 µg
EUR 703.2

Anti-PELO Antibody (Biotin)

STJ502412 100 µg
EUR 703.2

Anti-NPR1 Antibody (Biotin)

STJ502454 100 µg
EUR 703.2

Anti-NPR2 Antibody (Biotin)

STJ502457 100 µg
EUR 703.2

Anti-PGCD Antibody BIOTIN

STJ502463 100 µg
EUR 703.2

Anti-PGCE Antibody BIOTIN

STJ502466 100 µg
EUR 703.2

Anti-PGCF Antibody BIOTIN

STJ502469 100 µg
EUR 703.2

Anti-PGCG Antibody BIOTIN

STJ502472 100 µg
EUR 703.2

Anti-Pin1 Antibody BIOTIN

STJ502497 100 µg
EUR 703.2

Anti-Pin1 Antibody BIOTIN

STJ502499 100 µg
EUR 703.2

Anti-PMS2 Antibody (Biotin)

STJ502563 100 µg
EUR 703.2

Anti-PMS2 Antibody BIOTIN

STJ502565 100 µg
EUR 703.2

Anti-POP4 Antibody (Biotin)

STJ502587 100 µg
EUR 703.2

Anti-POP4 Antibody (Biotin)

STJ502589 100 µg
EUR 703.2

Anti-Punt Antibody BIOTIN

STJ502731 100 µg
EUR 703.2

Anti-Punt Antibody BIOTIN

STJ502733 100 µg
EUR 703.2

Anti-RBP2 Antibody BIOTIN

STJ502757 100 µg
EUR 703.2

Anti-RCE1 Antibody (Biotin)

STJ502760 100 µg
EUR 703.2

Anti-RRF3 Antibody BIOTIN

STJ502765 100 µg
EUR 703.2

Anti-RRF3 Antibody BIOTIN

STJ502767 100 µg
EUR 703.2

Anti-RRF3 Antibody BIOTIN

STJ502769 100 µg
EUR 703.2

Anti-REST Antibody (Biotin)

STJ502772 100 µg
EUR 703.2

Anti-ROR1 Antibody BIOTIN

STJ502826 100 µg
EUR 703.2

Anti-ROR2 Antibody (Biotin)

STJ502829 100 µg
EUR 703.2

Anti-EDG8 Antibody BIOTIN

STJ502856 100 µg
EUR 703.2

Anti-SARA Antibody BIOTIN

STJ502879 100 µg
EUR 703.2

Anti-SARA Antibody BIOTIN

STJ502881 100 µg
EUR 703.2

Anti-SARA Antibody BIOTIN

STJ502883 100 µg
EUR 703.2

Anti-SGK1 Antibody (Biotin)

STJ502979 100 µg
EUR 703.2

Anti-SGK2 Antibody (Biotin)

STJ502982 100 µg
EUR 703.2

Anti-SSH1 Antibody (Biotin)

STJ503048 100 µg
EUR 703.2

Anti-SMOX Antibody BIOTIN

STJ503072 100 µg
EUR 703.2

Anti-NAPA Antibody (Biotin)

STJ503075 100 µg
EUR 703.2

Anti-SOX2 Antibody BIOTIN

STJ503094 100 µg
EUR 703.2

Anti-SOX2 Antibody BIOTIN

STJ503096 100 µg
EUR 703.2

Anti-SUR1 Antibody BIOTIN

STJ503162 100 µg
EUR 703.2

Anti-SDC1 Antibody (Biotin)

STJ503193 100 µg
EUR 703.2

Here, we demonstrate for the first time that histone H3K 4 SETD1A methyltransferase is the main regulator of the proliferation of metastatic CRPC (mCRPC). SETD1A expression was significantly correlated with survival rate of patients with prostate cancer.