Induced pluripotent stem (iPS) cells are laboratory-produced cells that combine the advantages of biological and adult somatic stem cells for cell-based therapies. The reprogramming of cells, such as fibroblasts, into embryonic stem cell-like state is done by ectopic expression of transcription factor is responsible for generating embryonic stem cell properties.

This primer factor is octamer – bind transcription factor 4 (Oct3 / 4 ), sex determining region Y-box 2 (Sox2), Krüppel like factor 4 (Klf 4 ), and the proto-oncogene homolog protein from bird myelocytomatosis (c-Myc). Somatic cells can be easily obtained from the patient to be subjected to cell therapy and reprogrammed to obtain necessary high plasticity of embryonic stem cells.

These cells have no ethical limitations were involved, as in the case of embryonic stem cells, and displays minimal risk of immunologic rejection after transplantation. Currently, several ongoing clinical trials, most of them in Phase I or II. However, some of the inherent risks, such as chromosomal instability, insertional tumor, and teratoma formation, must be overcome to achieve full clinical translation. However, clinical trials and extensive basic research studying the biology of these cells, a promising future for the human cell-based therapy using iPS cells seem to be more clear and close.

Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies
Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies

Dexamethasone inhibits stemness Improving maintenance and chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation HIF-1α and Oct4

It has been controversial whether patients with hepatocellular carcinoma (HCC) should receive glucocorticoid therapy during chemotherapy. Recent studies have shown that glucocorticoids increase the sensitivity of tumor therapy for some chemotherapy drugs, but the specific mechanism remains unclear. In this study, dexamethasone (Dex) is used for stem cells to treat HCC. The results showed that Dex reduced maintenance stemness and self-renewal of cells HCC stem, promoted the epithelial-to-mesenchymal transition, migration inhibiting and angiogenesis and, more importantly, increase the sensitivity of cells to herpes simplex virus thymidine kinase / ganciclovir system of medicine in vitro and in vivo.

Further mechanistic analysis showed that Dex inhibits small ubiquitin-like modifier (SUMO) modification of some proteins in HCC stem cells, including hypoxia inducible factor (HIF) -1α, protein hypoxia tolerance is important, and octamer – bind transcription factor 4 (October 4 ), stemness protein essential maintenance. DeSUMOylation encourage HIF-1α and October 4 reduced their accumulation in the nucleus, thereby inhibiting tumor angiogenesis and maintenance of stemness.

This finding provides a new perspective to study the mechanisms underlying the effects of anti-hepatocarcinogenesis of Dex. Because of the side effects of glucocorticoids on low-dose anti-inflammatory effect, the right combination of glucocorticoids and chemotherapy drugs are expected to improve the survival of HCC patients and their prognosis.Androgen deprivation therapy eventually lead to the development castration- resistant prostate cancer (CRPC)

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E05-105-500g 500 g
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E05-110-10kg 10 kg
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E05-110-500g 500 g
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A01-101-10kg 10 kg
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A01-101-2Kg 2 Kg
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APT AGAR

A01-101-500g 500 g
EUR 116

AGAR, BACTERIOLOGICAL

A01-102-10kg 10 kg
EUR 1684

AGAR, BACTERIOLOGICAL

A01-102-2kg 2kg
EUR 405

AGAR, BACTERIOLOGICAL

A01-102-500g 500 g
EUR 146

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A01-102IHG-10kg 10 kg
EUR 2219

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A01-102IHG-2Kg 2 Kg
EUR 521

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A01-102IHG-500g 500 g
EUR 178

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A01-102N-10kg 10 kg
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A01-102N-2kg 2kg
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A01-102N-500g 500 g
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A01-113-10kg 10 kg
EUR 2532

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A01-113-2kg 2kg
EUR 589

AZIDE BLOOD AGAR BASE

A01-113-500g 500 g
EUR 197

AZIDE DEXTROSE BROTH

A01-114-10kg 10 kg
EUR 868

AZIDE DEXTROSE BROTH

A01-114-2Kg 2 Kg
EUR 228

AZIDE DEXTROSE BROTH

A01-114-500g 500 g
EUR 98

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A01-115-10kg 10 kg
EUR 2556

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A01-115-2kg 2kg
EUR 595

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A01-115-500g 500 g
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A01-116-10kg 10 kg
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A01-116-2Kg 2 Kg
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A01-118-500g 500 g
EUR 494

IL-2 Receptor ?, Human Recombinant

7100-10
EUR 196

IL-2 Receptor ?, Human Recombinant

7100-50
EUR 637

Human CellExp? IL-4 R?, Human Recombinant

7101-10
EUR 229

Human CellExp? IL-4 R?, Human Recombinant

7101-50
EUR 881

Human CellExp? IL-6 R?, Human Recombinant

7102-10
EUR 207

Human CellExp? IL-6 R?, Human Recombinant

7102-50
EUR 800

IL-9, Rat Recombinant

7103-10
EUR 278

IL-9, Rat Recombinant

7103-50
EUR 1132

IL-12p80, Human Recombinant

7104-10
EUR 392

IL-12p80, Human Recombinant

7104-50
EUR 1675

IL-17A, Mouse Recombinant

7105-10
EUR 196

IL-17A, Mouse Recombinant

7105-50
EUR 675

IL-17B, Human Recombinant

7106-10
EUR 196

IL-17B, Human Recombinant

7106-50
EUR 675

IL-17D, Human Recombinant

7107-10
EUR 196

IL-17D, Human Recombinant

7107-50
EUR 675

Human CellExp? IL-34, Human Recombinant

7108-10
EUR 278

Human CellExp? IL-34, Human Recombinant

7108-50
EUR 1132

IL-36RA, Human Recombinant

7109-10
EUR 196

IL-36RA, Human Recombinant

7109-50
EUR 675

IL-36?, Human Recombinant

7110-10
EUR 278

IL-36?, Human Recombinant

7110-50
EUR 1132

IL-36?, Human Recombinant

7111-10
EUR 278

IL-36?, Human Recombinant

7111-50
EUR 1132

Activin B, Human Recombinant

7112-10
EUR 479

Activin B, Human Recombinant

7112-50
EUR 2094

AITRL, Human Recombinant

7113-10
EUR 251

AITRL, Human Recombinant

7113-50
EUR 936

Amphiregulin, Human Recombinant

7114-10
EUR 147

Amphiregulin, Human Recombinant

7114-50
EUR 376

ANG-1, Human Recombinant

7115-10
EUR 251

ANG-1, Human Recombinant

7115-50
EUR 936

ANG-2, Human Recombinant

7116-10
EUR 251

ANG-2, Human Recombinant

7116-50
EUR 936

APRIL, Human Recombinant

7117-10
EUR 311

APRIL, Human Recombinant

7117-50
EUR 1300

APRIL, Mouse Recombinant

7118-10
EUR 196

APRIL, Mouse Recombinant

7118-50
EUR 675

Betacellulin, Murine Recombinant

7119-10
EUR 196

Betacellulin, Murine Recombinant

7119-50
EUR 675

Cardiotrophin-1, Murine Recombinant

7121-10
EUR 278

Cardiotrophin-1, Murine Recombinant

7121-50
EUR 1132

sCD100/Semaphorin-4D, Human Recombinant

7126-10
EUR 251

sCD100/Semaphorin-4D, Human Recombinant

7126-50
EUR 936

CTGFL/WISP-2, Human Recombinant

7129-10
EUR 234

CTGFL/WISP-2, Human Recombinant

7129-50
EUR 860

Human CellExp? DKK-1, Human Recombinant

7132-10
EUR 278

Human CellExp? DKK-1, Human Recombinant

7132-50
EUR 1132

Human CellExp? sDLL-1, Human Recombinant

7133-10
EUR 207

Human CellExp? sDLL-1, Human Recombinant

7133-50
EUR 675

Human CellExp? sDLL-4, Human Recombinant

7134-10
EUR 207

Human CellExp? sDLL-4, Human Recombinant

7134-50
EUR 675

Eotaxin-2/CCL24, murine recombinant

7137-10
EUR 207

Eotaxin-2/CCL24, murine recombinant

7137-50
EUR 675

Eotaxin-3/CCL26, human recombinant

7138-10
EUR 207

Eotaxin-3/CCL26, human recombinant

7138-50
EUR 675

Human CellExp? Fetuin A/ASHG, Human Recombinant

7142-10
EUR 153

Human CellExp? Fetuin A/ASHG, Human Recombinant

7142-50
EUR 381

Histone H3 Peptide, biotin conjugate

7143-01
EUR 240

Histone H3 Peptide, biotin conjugate

7143-1
EUR 1132

Histone H4 Peptide, tetra-acetylated, biotin conjugate

7144-01
EUR 240

Histone H4 Peptide, tetra-acetylated, biotin conjugate

7144-1
EUR 1132

FGF-5, human recombinant

7147-10
EUR 142

FGF-5, human recombinant

7147-50
EUR 359

FGF-6, human recombinant

7148-10
EUR 207

FGF-6, human recombinant

7148-50
EUR 675

FGF-16, human recombinant

7149-10
EUR 207

FGF-16, human recombinant

7149-50
EUR 675

FGF-17, human recombinant

7150-10
EUR 207

FGF-17, human recombinant

7150-50
EUR 675

FGF-23, human recombinant

7151-10
EUR 229

FGF-23, human recombinant

7151-50
EUR 860

GASP-1, human recombinant

7152-10
EUR 229

GASP-1, human recombinant

7152-50
EUR 833

GCP-2 (CXCL6), human recombinant

7153-10
EUR 207

GCP-2 (CXCL6), human recombinant

7153-50
EUR 675

BMP-9/GDF-2, human recombinant

7154-10
EUR 278

BMP-9/GDF-2, human recombinant

7154-50
EUR 1132

BMP-11/GDF-11, human recombinant

7155-10
EUR 240

BMP-11/GDF-11, human recombinant

7155-50
EUR 860

Gremlin-1, human recombinant

7159-10
EUR 142

Gremlin-1, human recombinant

7159-50
EUR 359

ICAM-1, human recombinant

7161-10
EUR 142

ICAM-1, human recombinant

7161-50
EUR 359

IFN-?1, human recombinant

7162-10
EUR 207

IFN-?1, human recombinant

7162-50
EUR 735

IFN-?2, human recombinant

7163-10
EUR 207

IFN-?2, human recombinant

7163-50
EUR 675

IGF-BP2, human recombinant

7165-10
EUR 251

IGF-BP2, human recombinant

7165-50
EUR 936

IGF-BP4, human recombinant

7166-10
EUR 251

IGF-BP4, human recombinant

7166-50
EUR 936

IGF-BP7, human recombinant

7167-10
EUR 207

IGF-BP7, human recombinant

7167-50
EUR 675

MCP-5/CCL12, murine recombinant

7168-10
EUR 207

MCP-5/CCL12, murine recombinant

7168-50
EUR 675

MIP-1?/CCL3, human recombinant

7173-10
EUR 207

MIP-1?/CCL3, human recombinant

7173-50
EUR 675

MIP-1?/CCL9/10, murine recombinant

7174-10
EUR 207

MIP-1?/CCL9/10, murine recombinant

7174-50
EUR 675

MIP-3/CCL23, human recombinant

7175-10
EUR 207

MIP-3/CCL23, human recombinant

7175-50
EUR 675

Nesfatin-1, human recombinant

7178-10
EUR 137

Nesfatin-1, human recombinant

7178-50
EUR 272

Human CellExp? PECAM-1, Human Recombinant

7184-10
EUR 153

Human CellExp? PECAM-1, Human Recombinant

7184-50
EUR 381

PF-4/CXCL4, murine recombinant

7187-10
EUR 207

PF-4/CXCL4, murine recombinant

7187-50
EUR 675

R-Spondin-1, human recombinant

7189-10
EUR 207

R-Spondin-1, human recombinant

7189-50
EUR 675

R-Spondin-2, human recombinant

7190-10
EUR 207

R-Spondin-2, human recombinant

7190-50
EUR 675

R-Spondin-3, human recombinant

7191-10
EUR 207

Here, we demonstrate for the first time that histone H3K 4 SETD1A methyltransferase is the main regulator of the proliferation of metastatic CRPC (mCRPC). SETD1A expression was significantly correlated with survival rate of patients with prostate cancer.