Induced pluripotent stem (iPS) cells are laboratory-produced cells that combine the advantages of biological and adult somatic stem cells for cell-based therapies. The reprogramming of cells, such as fibroblasts, into embryonic stem cell-like state is done by ectopic expression of transcription factor is responsible for generating embryonic stem cell properties.
This primer factor is octamer – bind transcription factor 4 (Oct3 / 4 ), sex determining region Y-box 2 (Sox2), Krüppel like factor 4 (Klf 4 ), and the proto-oncogene homolog protein from bird myelocytomatosis (c-Myc). Somatic cells can be easily obtained from the patient to be subjected to cell therapy and reprogrammed to obtain necessary high plasticity of embryonic stem cells.
These cells have no ethical limitations were involved, as in the case of embryonic stem cells, and displays minimal risk of immunologic rejection after transplantation. Currently, several ongoing clinical trials, most of them in Phase I or II. However, some of the inherent risks, such as chromosomal instability, insertional tumor, and teratoma formation, must be overcome to achieve full clinical translation. However, clinical trials and extensive basic research studying the biology of these cells, a promising future for the human cell-based therapy using iPS cells seem to be more clear and close.
Dexamethasone inhibits stemness Improving maintenance and chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation HIF-1α and Oct4
It has been controversial whether patients with hepatocellular carcinoma (HCC) should receive glucocorticoid therapy during chemotherapy. Recent studies have shown that glucocorticoids increase the sensitivity of tumor therapy for some chemotherapy drugs, but the specific mechanism remains unclear. In this study, dexamethasone (Dex) is used for stem cells to treat HCC. The results showed that Dex reduced maintenance stemness and self-renewal of cells HCC stem, promoted the epithelial-to-mesenchymal transition, migration inhibiting and angiogenesis and, more importantly, increase the sensitivity of cells to herpes simplex virus thymidine kinase / ganciclovir system of medicine in vitro and in vivo.
Further mechanistic analysis showed that Dex inhibits small ubiquitin-like modifier (SUMO) modification of some proteins in HCC stem cells, including hypoxia inducible factor (HIF) -1α, protein hypoxia tolerance is important, and octamer – bind transcription factor 4 (October 4 ), stemness protein essential maintenance. DeSUMOylation encourage HIF-1α and October 4 reduced their accumulation in the nucleus, thereby inhibiting tumor angiogenesis and maintenance of stemness.
This finding provides a new perspective to study the mechanisms underlying the effects of anti-hepatocarcinogenesis of Dex. Because of the side effects of glucocorticoids on low-dose anti-inflammatory effect, the right combination of glucocorticoids and chemotherapy drugs are expected to improve the survival of HCC patients and their prognosis.Androgen deprivation therapy eventually lead to the development castration- resistant prostate cancer (CRPC)
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APT AGAR |
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APT AGAR |
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 AGAR, BACTERIOLOGICAL |
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AGAR, BACTERIOLOGICAL |
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AGAR, BACTERIOLOGICAL |
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 AGAR, HIGH GEL |
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| A01-113-500g | Alphabiosciences | 500 g | EUR 197 |
 AZIDE DEXTROSE BROTH |
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| A01-114-10kg | Alphabiosciences | 10 kg | EUR 868 |
AZIDE DEXTROSE BROTH |
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AZIDE DEXTROSE BROTH |
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 IL-2 Receptor ?, Human Recombinant |
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| 7100-10 | Biovision | EUR 196 | |
IL-2 Receptor ?, Human Recombinant |
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| 7100-50 | Biovision | EUR 637 | |
 Human CellExp? IL-4 R?, Human Recombinant |
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| 7101-10 | Biovision | EUR 229 | |
Human CellExp? IL-4 R?, Human Recombinant |
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| 7101-50 | Biovision | EUR 881 | |
 Human CellExp? IL-6 R?, Human Recombinant |
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| 7102-10 | Biovision | EUR 207 | |
Human CellExp? IL-6 R?, Human Recombinant |
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| 7102-50 | Biovision | EUR 800 | |
 IL-9, Rat Recombinant |
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| 7103-10 | Biovision | EUR 278 | |
IL-9, Rat Recombinant |
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| 7103-50 | Biovision | EUR 1132 | |
 IL-12p80, Human Recombinant |
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| 7104-10 | Biovision | EUR 392 | |
IL-12p80, Human Recombinant |
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| 7104-50 | Biovision | EUR 1675 | |
 IL-17A, Mouse Recombinant |
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| 7105-10 | Biovision | EUR 196 | |
IL-17A, Mouse Recombinant |
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| 7105-50 | Biovision | EUR 675 | |
 IL-17B, Human Recombinant |
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| 7106-10 | Biovision | EUR 196 | |
IL-17B, Human Recombinant |
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| 7106-50 | Biovision | EUR 675 | |
 IL-17D, Human Recombinant |
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| 7107-10 | Biovision | EUR 196 | |
IL-17D, Human Recombinant |
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| 7107-50 | Biovision | EUR 675 | |
 Human CellExp? IL-34, Human Recombinant |
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| 7108-10 | Biovision | EUR 278 | |
Human CellExp? IL-34, Human Recombinant |
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| 7108-50 | Biovision | EUR 1132 | |
 IL-36RA, Human Recombinant |
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| 7109-10 | Biovision | EUR 196 | |
IL-36RA, Human Recombinant |
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| 7109-50 | Biovision | EUR 675 | |
 IL-36?, Human Recombinant |
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| 7110-10 | Biovision | EUR 278 | |
IL-36?, Human Recombinant |
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| 7110-50 | Biovision | EUR 1132 | |
IL-36?, Human Recombinant |
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| 7111-10 | Biovision | EUR 278 | |
IL-36?, Human Recombinant |
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| 7111-50 | Biovision | EUR 1132 | |
 Activin B, Human Recombinant |
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| 7112-10 | Biovision | EUR 479 | |
Activin B, Human Recombinant |
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| 7112-50 | Biovision | EUR 2094 | |
 AITRL, Human Recombinant |
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| 7113-10 | Biovision | EUR 251 | |
AITRL, Human Recombinant |
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| 7113-50 | Biovision | EUR 936 | |
 Amphiregulin, Human Recombinant |
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| 7114-10 | Biovision | EUR 147 | |
Amphiregulin, Human Recombinant |
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| 7114-50 | Biovision | EUR 376 | |
 ANG-1, Human Recombinant |
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| 7115-10 | Biovision | EUR 251 | |
ANG-1, Human Recombinant |
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| 7115-50 | Biovision | EUR 936 | |
 ANG-2, Human Recombinant |
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| 7116-10 | Biovision | EUR 251 | |
ANG-2, Human Recombinant |
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| 7116-50 | Biovision | EUR 936 | |
 APRIL, Human Recombinant |
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| 7117-10 | Biovision | EUR 311 | |
APRIL, Human Recombinant |
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| 7117-50 | Biovision | EUR 1300 | |
 APRIL, Mouse Recombinant |
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| 7118-10 | Biovision | EUR 196 | |
APRIL, Mouse Recombinant |
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| 7118-50 | Biovision | EUR 675 | |
 Betacellulin, Murine Recombinant |
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| 7119-10 | Biovision | EUR 196 | |
Betacellulin, Murine Recombinant |
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| 7119-50 | Biovision | EUR 675 | |
 Cardiotrophin-1, Murine Recombinant |
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| 7121-10 | Biovision | EUR 278 | |
Cardiotrophin-1, Murine Recombinant |
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| 7121-50 | Biovision | EUR 1132 | |
 sCD100/Semaphorin-4D, Human Recombinant |
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| 7126-10 | Biovision | EUR 251 | |
sCD100/Semaphorin-4D, Human Recombinant |
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| 7126-50 | Biovision | EUR 936 | |
 CTGFL/WISP-2, Human Recombinant |
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| 7129-10 | Biovision | EUR 234 | |
CTGFL/WISP-2, Human Recombinant |
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| 7129-50 | Biovision | EUR 860 | |
 Human CellExp? DKK-1, Human Recombinant |
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| 7132-10 | Biovision | EUR 278 | |
Human CellExp? DKK-1, Human Recombinant |
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| 7132-50 | Biovision | EUR 1132 | |
 Human CellExp? sDLL-1, Human Recombinant |
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| 7133-10 | Biovision | EUR 207 | |
Human CellExp? sDLL-1, Human Recombinant |
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| 7133-50 | Biovision | EUR 675 | |
 Human CellExp? sDLL-4, Human Recombinant |
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| 7134-10 | Biovision | EUR 207 | |
Human CellExp? sDLL-4, Human Recombinant |
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| 7134-50 | Biovision | EUR 675 | |
 Eotaxin-2/CCL24, murine recombinant |
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| 7137-10 | Biovision | EUR 207 | |
Eotaxin-2/CCL24, murine recombinant |
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| 7137-50 | Biovision | EUR 675 | |
 Eotaxin-3/CCL26, human recombinant |
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| 7138-10 | Biovision | EUR 207 | |
Eotaxin-3/CCL26, human recombinant |
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| 7138-50 | Biovision | EUR 675 | |
 Human CellExp? Fetuin A/ASHG, Human Recombinant |
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| 7142-10 | Biovision | EUR 153 | |
Human CellExp? Fetuin A/ASHG, Human Recombinant |
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| 7142-50 | Biovision | EUR 381 | |
 Histone H3 Peptide, biotin conjugate |
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| 7143-01 | Biovision | EUR 240 | |
Histone H3 Peptide, biotin conjugate |
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| 7143-1 | Biovision | EUR 1132 | |
 Histone H4 Peptide, tetra-acetylated, biotin conjugate |
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| 7144-01 | Biovision | EUR 240 | |
Histone H4 Peptide, tetra-acetylated, biotin conjugate |
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| 7144-1 | Biovision | EUR 1132 | |
 FGF-5, human recombinant |
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| 7147-10 | Biovision | EUR 142 | |
FGF-5, human recombinant |
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 FGF-6, human recombinant |
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| 7148-10 | Biovision | EUR 207 | |
FGF-6, human recombinant |
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| 7148-50 | Biovision | EUR 675 | |
 FGF-16, human recombinant |
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| 7149-10 | Biovision | EUR 207 | |
FGF-16, human recombinant |
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| 7149-50 | Biovision | EUR 675 | |
 FGF-17, human recombinant |
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| 7150-10 | Biovision | EUR 207 | |
FGF-17, human recombinant |
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| 7150-50 | Biovision | EUR 675 | |
 FGF-23, human recombinant |
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| 7151-10 | Biovision | EUR 229 | |
FGF-23, human recombinant |
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| 7151-50 | Biovision | EUR 860 | |
 GASP-1, human recombinant |
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| 7152-10 | Biovision | EUR 229 | |
GASP-1, human recombinant |
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| 7152-50 | Biovision | EUR 833 | |
, human recombinant) GCP-2 (CXCL6), human recombinant |
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| 7153-10 | Biovision | EUR 207 | |
GCP-2 (CXCL6), human recombinant |
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 BMP-9/GDF-2, human recombinant |
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| 7154-10 | Biovision | EUR 278 | |
BMP-9/GDF-2, human recombinant |
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| 7154-50 | Biovision | EUR 1132 | |
 BMP-11/GDF-11, human recombinant |
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| 7155-10 | Biovision | EUR 240 | |
BMP-11/GDF-11, human recombinant |
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| 7155-50 | Biovision | EUR 860 | |
 Gremlin-1, human recombinant |
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| 7159-10 | Biovision | EUR 142 | |
Gremlin-1, human recombinant |
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| 7159-50 | Biovision | EUR 359 | |
 ICAM-1, human recombinant |
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| 7161-10 | Biovision | EUR 142 | |
ICAM-1, human recombinant |
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| 7161-50 | Biovision | EUR 359 | |
 IFN-?1, human recombinant |
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| 7162-10 | Biovision | EUR 207 | |
IFN-?1, human recombinant |
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| 7162-50 | Biovision | EUR 735 | |
 IFN-?2, human recombinant |
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| 7163-10 | Biovision | EUR 207 | |
IFN-?2, human recombinant |
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| 7163-50 | Biovision | EUR 675 | |
 IGF-BP2, human recombinant |
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| 7165-10 | Biovision | EUR 251 | |
IGF-BP2, human recombinant |
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| 7165-50 | Biovision | EUR 936 | |
 IGF-BP4, human recombinant |
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| 7166-10 | Biovision | EUR 251 | |
IGF-BP4, human recombinant |
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| 7166-50 | Biovision | EUR 936 | |
 IGF-BP7, human recombinant |
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| 7167-10 | Biovision | EUR 207 | |
IGF-BP7, human recombinant |
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| 7167-50 | Biovision | EUR 675 | |
 MCP-5/CCL12, murine recombinant |
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| 7168-10 | Biovision | EUR 207 | |
MCP-5/CCL12, murine recombinant |
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| 7168-50 | Biovision | EUR 675 | |
 MIP-1?/CCL3, human recombinant |
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| 7173-10 | Biovision | EUR 207 | |
MIP-1?/CCL3, human recombinant |
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| 7173-50 | Biovision | EUR 675 | |
 MIP-1?/CCL9/10, murine recombinant |
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| 7174-10 | Biovision | EUR 207 | |
MIP-1?/CCL9/10, murine recombinant |
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| 7174-50 | Biovision | EUR 675 | |
 MIP-3/CCL23, human recombinant |
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| 7175-10 | Biovision | EUR 207 | |
MIP-3/CCL23, human recombinant |
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| 7175-50 | Biovision | EUR 675 | |
 Nesfatin-1, human recombinant |
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| 7178-10 | Biovision | EUR 137 | |
Nesfatin-1, human recombinant |
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| 7178-50 | Biovision | EUR 272 | |
 Human CellExp? PECAM-1, Human Recombinant |
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| 7184-10 | Biovision | EUR 153 | |
Human CellExp? PECAM-1, Human Recombinant |
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| 7184-50 | Biovision | EUR 381 | |
 PF-4/CXCL4, murine recombinant |
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| 7187-10 | Biovision | EUR 207 | |
PF-4/CXCL4, murine recombinant |
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| 7187-50 | Biovision | EUR 675 | |
 R-Spondin-1, human recombinant |
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| 7189-10 | Biovision | EUR 207 | |
R-Spondin-1, human recombinant |
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| 7189-50 | Biovision | EUR 675 | |
 R-Spondin-2, human recombinant |
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| 7190-10 | Biovision | EUR 207 | |
R-Spondin-2, human recombinant |
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| 7190-50 | Biovision | EUR 675 | |
 R-Spondin-3, human recombinant |
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| 7191-10 | Biovision | EUR 207 | |
Here, we demonstrate for the first time that histone H3K 4 SETD1A methyltransferase is the main regulator of the proliferation of metastatic CRPC (mCRPC). SETD1A expression was significantly correlated with survival rate of patients with prostate cancer.
