Induced pluripotent stem (iPS) cells are laboratory-produced cells that combine the advantages of biological and adult somatic stem cells for cell-based therapies. The reprogramming of cells, such as fibroblasts, into embryonic stem cell-like state is done by ectopic expression of transcription factor is responsible for generating embryonic stem cell properties.

This primer factor is octamer – bind transcription factor 4 (Oct3 / 4 ), sex determining region Y-box 2 (Sox2), Krüppel like factor 4 (Klf 4 ), and the proto-oncogene homolog protein from bird myelocytomatosis (c-Myc). Somatic cells can be easily obtained from the patient to be subjected to cell therapy and reprogrammed to obtain necessary high plasticity of embryonic stem cells.

These cells have no ethical limitations were involved, as in the case of embryonic stem cells, and displays minimal risk of immunologic rejection after transplantation. Currently, several ongoing clinical trials, most of them in Phase I or II. However, some of the inherent risks, such as chromosomal instability, insertional tumor, and teratoma formation, must be overcome to achieve full clinical translation. However, clinical trials and extensive basic research studying the biology of these cells, a promising future for the human cell-based therapy using iPS cells seem to be more clear and close.

Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies
Induced Pluripotent Stem Cells: Hope in the Treatment of Diseases, including Muscular Dystrophies

Dexamethasone inhibits stemness Improving maintenance and chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation HIF-1α and Oct4

It has been controversial whether patients with hepatocellular carcinoma (HCC) should receive glucocorticoid therapy during chemotherapy. Recent studies have shown that glucocorticoids increase the sensitivity of tumor therapy for some chemotherapy drugs, but the specific mechanism remains unclear. In this study, dexamethasone (Dex) is used for stem cells to treat HCC. The results showed that Dex reduced maintenance stemness and self-renewal of cells HCC stem, promoted the epithelial-to-mesenchymal transition, migration inhibiting and angiogenesis and, more importantly, increase the sensitivity of cells to herpes simplex virus thymidine kinase / ganciclovir system of medicine in vitro and in vivo.

Further mechanistic analysis showed that Dex inhibits small ubiquitin-like modifier (SUMO) modification of some proteins in HCC stem cells, including hypoxia inducible factor (HIF) -1α, protein hypoxia tolerance is important, and octamer – bind transcription factor 4 (October 4 ), stemness protein essential maintenance. DeSUMOylation encourage HIF-1α and October 4 reduced their accumulation in the nucleus, thereby inhibiting tumor angiogenesis and maintenance of stemness.

This finding provides a new perspective to study the mechanisms underlying the effects of anti-hepatocarcinogenesis of Dex. Because of the side effects of glucocorticoids on low-dose anti-inflammatory effect, the right combination of glucocorticoids and chemotherapy drugs are expected to improve the survival of HCC patients and their prognosis.Androgen deprivation therapy eventually lead to the development castration- resistant prostate cancer (CRPC)

LIN28 antibody

10R-2014 100 ul
EUR 522
Description: Mouse monoclonal LIN28 antibody

Lin28 Antibody

25055-100ul 100ul
EUR 468

Lin28 Antibody

21426-100ul 100ul
EUR 302.4

Lin28 Antibody

21426-50ul 50ul
EUR 224.4

Lin28 antibody

20R-2501 50 ug
EUR 337.2
Description: Rabbit polyclonal Lin28 antibody

Lin28 antibody

3091-200 each
EUR 379.2

Lin28 antibody

3091-30T each
EUR 175.2

LIN28 Antibody

BF0638 200ul
EUR 540

LIN28 Antibody

F41528-0.08ML 0.08 ml
EUR 140.25
Description: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

LIN28 Antibody

F41528-0.4ML 0.4 ml
EUR 322.15
Description: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.

LIN37 Antibody (Biotin)

20-abx309144
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Anti-Noelin Antibody BIOTIN Antibody BIOTIN

STJ501938 100 µg
EUR 703.2

Anti-Noelin Antibody BIOTIN Antibody BIOTIN

STJ501940 100 µg
EUR 703.2

Lin28 Antibody [1G9H9]

PM-6143-002mg 0.02 mg
EUR 206.18
Description: Lin28 Monoclonal Antibody: Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

Lin28 Antibody [1G9H9]

PM-6143-01mg 0.1 mg
EUR 523.7
Description: Lin28 Monoclonal Antibody: Lin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.

LIN28 (pS134) Antibody

abx032091-400ul 400 ul
EUR 627.6

LIN28 (pS134) Antibody

abx032091-80l 80 µl
EUR 343.2

Polyclonal Lin28 Antibody

AMM06296G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Lin28 . This antibody is tested and proven to work in the following applications:

Polyclonal LIN28 Antibody

AMM06297G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human LIN28 . This antibody is tested and proven to work in the following applications:

Lin28 Conjugated Antibody

C49538 100ul
EUR 476.4

Lin28 Conjugated Antibody

C21426 100ul
EUR 476.4

LIN37 Antibody, Biotin conjugated

1-CSB-PA836222LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LIN37. Recognizes LIN37 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

LIN9 Antibody, Biotin conjugated

1-CSB-PA716370LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LIN9. Recognizes LIN9 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

LIN28B Antibody, Biotin conjugated

1-CSB-PA741049LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LIN28B. Recognizes LIN28B from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

LIN28A Antibody, Biotin conjugated

1-CSB-PA13619D0Rb
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LIN28A. Recognizes LIN28A from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Anti-LIN28 antibody

PAab04783 100 ug
EUR 426

Anti-B19 Antibody BIOTIN

STJ501375 100 µg
EUR 703.2

Anti-MB Antibody (Biotin)

STJ501832 100 µg
EUR 703.2

Anti-BLK Antibody (Biotin)

STJ500259 100 µg
EUR 703.2

Anti-BTK Antibody (Biotin)

STJ500304 100 µg
EUR 703.2

Anti-Brk Antibody BIOTIN

STJ502712 100 µg
EUR 703.2

Anti-AFP Antibody (Biotin)

STJ500052 100 µg
EUR 703.2

Anti-AGE Antibody BIOTIN

STJ500055 100 µg
EUR 703.2

Anti-AQR Antibody (Biotin)

STJ500151 100 µg
EUR 703.2

Anti-Axl Antibody BIOTIN

STJ500199 100 µg
EUR 703.2

Anti-C4A Antibody (Biotin)

STJ500328 100 µg
EUR 703.2

Anti-CD2 Antibody (Biotin)

STJ500437 100 µg
EUR 703.2

Anti-CD2 Antibody (Biotin)

STJ500439 100 µg
EUR 703.2

Anti-CR2 Antibody (Biotin)

STJ500443 100 µg
EUR 703.2

Anti-CR2 Antibody (Biotin)

STJ500445 100 µg
EUR 703.2

Anti-CD4 Antibody (Biotin)

STJ500470 100 µg
EUR 703.2

Anti-CD4 Antibody (Biotin)

STJ500472 100 µg
EUR 703.2

Anti-SHC Antibody BIOTIN

STJ503000 100 µg
EUR 703.2

Anti-SYK Antibody (Biotin)

STJ503183 100 µg
EUR 703.2

Anti-SYP Antibody (Biotin)

STJ503187 100 µg
EUR 703.2

Anti-SYP Antibody (Biotin)

STJ503189 100 µg
EUR 703.2

Anti-SRC Antibody (Biotin)

STJ503202 100 µg
EUR 703.2

Anti-SRC Antibody (Biotin)

STJ503204 100 µg
EUR 703.2

Anti-TEK Antibody (Biotin)

STJ503259 100 µg
EUR 703.2

Anti-TEK Antibody (Biotin)

STJ503261 100 µg
EUR 703.2

Anti-trp Antibody BIOTIN

STJ503409 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500565 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500568 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500570 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500572 100 µg
EUR 703.2

Anti-KIT Antibody (Biotin)

STJ500574 100 µg
EUR 703.2

Anti-MYC Antibody (Biotin)

STJ500593 100 µg
EUR 703.2

Anti-MYC Antibody (Biotin)

STJ500595 100 µg
EUR 703.2

Anti-DCC Antibody (Biotin)

STJ500739 100 µg
EUR 703.2

Anti-DCK Antibody BIOTIN

STJ500742 100 µg
EUR 703.2

Anti-DEK Antibody (Biotin)

STJ500751 100 µg
EUR 703.2

Anti-ERG Antibody (Biotin)

STJ500950 100 µg
EUR 703.2

Anti-ERG Antibody (Biotin)

STJ500952 100 µg
EUR 703.2

Anti-FGR Antibody (Biotin)

STJ501047 100 µg
EUR 703.2

Anti-FSH Antibody BIOTIN

STJ501089 100 µg
EUR 703.2

Anti-FYN Antibody (Biotin)

STJ501110 100 µg
EUR 703.2

Anti-GFP Antibody BIOTIN

STJ501149 100 µg
EUR 703.2

Anti-GBA Antibody (Biotin)

STJ501179 100 µg
EUR 703.2

Anti-LTF Antibody (Biotin)

STJ501354 100 µg
EUR 703.2

Anti-LTF Antibody (Biotin)

STJ501356 100 µg
EUR 703.2

Anti-ILK Antibody (Biotin)

STJ501450 100 µg
EUR 703.2

Anti-ITK Antibody (Biotin)

STJ501510 100 µg
EUR 703.2

Anti-LCT Antibody BIOTIN

STJ501565 100 µg
EUR 703.2

Anti-LAT Antibody (Biotin)

STJ501580 100 µg
EUR 703.2

Anti-LCK Antibody (Biotin)

STJ501586 100 µg
EUR 703.2

Anti-LYN Antibody (Biotin)

STJ501640 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501782 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501784 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501786 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501788 100 µg
EUR 703.2

Anti-MPO Antibody (Biotin)

STJ501790 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501901 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501903 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501905 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501907 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501909 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501911 100 µg
EUR 703.2

Anti-MME Antibody (Biotin)

STJ501913 100 µg
EUR 703.2

Anti-OGT Antibody (Biotin)

STJ502000 100 µg
EUR 703.2

Anti-PGR Antibody (Biotin)

STJ502476 100 µg
EUR 703.2

Anti-PGR Antibody (Biotin)

STJ502478 100 µg
EUR 703.2

Anti-PRL Antibody (Biotin)

STJ502656 100 µg
EUR 703.2

Anti-PRL Antibody (Biotin)

STJ502658 100 µg
EUR 703.2

Anti-VHL Antibody (Biotin)

STJ502736 100 µg
EUR 703.2

Anti-SFN Antibody (Biotin)

STJ502961 100 µg
EUR 703.2

LINC00299 Antibody (Biotin)

20-abx314553
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

LINC00846 Antibody (Biotin)

20-abx311645
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

LINC01553 Antibody (Biotin)

20-abx303235
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Anti-BCL6 Antibody (Biotin)

STJ500221 100 µg
EUR 703.2

Anti-BCL6 Antibody (Biotin)

STJ500224 100 µg
EUR 703.2

Anti-BCL6 Antibody (Biotin)

STJ500227 100 µg
EUR 703.2

Anti-BCL6 Antibody (Biotin)

STJ500229 100 µg
EUR 703.2

Anti-BMP1 Antibody (Biotin)

STJ500266 100 µg
EUR 703.2

Anti-BMP1 Antibody (Biotin)

STJ500268 100 µg
EUR 703.2

Anti-BMP2 Antibody BIOTIN

STJ500273 100 µg
EUR 703.2

Anti-BMP4 Antibody BIOTIN

STJ500275 100 µg
EUR 703.2

Anti-BRAF Antibody (Biotin)

STJ500283 100 µg
EUR 703.2

Anti-BST1 Antibody (Biotin)

STJ500286 100 µg
EUR 703.2

Anti-BST2 Antibody (Biotin)

STJ500291 100 µg
EUR 703.2

Anti-BST2 Antibody (Biotin)

STJ500293 100 µg
EUR 703.2

Anti-BST2 Antibody (Biotin)

STJ500295 100 µg
EUR 703.2

LIN7A Antibody, Biotin conjugated

1-CSB-PA012963LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against LIN7A. Recognizes LIN7A from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Anti-5HT1A Antibody BIOTIN

STJ500001 100 µg
EUR 703.2

Anti-5HT1B Antibody BIOTIN

STJ500004 100 µg
EUR 703.2

Anti-ABL1 Antibody (Biotin)

STJ500019 100 µg
EUR 703.2

Anti-TNK2 Antibody (Biotin)

STJ500028 100 µg
EUR 703.2

Anti-ACTH Antibody BIOTIN

STJ500037 100 µg
EUR 703.2

Anti-ACTB Antibody (Biotin)

STJ500040 100 µg
EUR 703.2

Anti-ACTB Antibody (Biotin)

STJ500043 100 µg
EUR 703.2

Anti-AIM2 Antibody (Biotin)

STJ500058 100 µg
EUR 703.2

Anti-AKT1 Antibody (Biotin)

STJ500061 100 µg
EUR 703.2

Anti-APLN Antibody (Biotin)

STJ500103 100 µg
EUR 703.2

Anti-AQP1 Antibody (Biotin)

STJ500115 100 µg
EUR 703.2

Anti-AQP4 Antibody (Biotin)

STJ500133 100 µg
EUR 703.2

Anti-ARF1 Antibody BIOTIN

STJ500154 100 µg
EUR 703.2

Anti-ARF4 Antibody BIOTIN

STJ500157 100 µg
EUR 703.2

Anti-CASR Antibody (Biotin)

STJ500367 100 µg
EUR 703.2

Anti-CCR1 Antibody (Biotin)

STJ500395 100 µg
EUR 703.2

Anti-CCR1 Antibody (Biotin)

STJ500397 100 µg
EUR 703.2

Anti-CCR2 Antibody (Biotin)

STJ500400 100 µg
EUR 703.2

Anti-CCR3 Antibody (Biotin)

STJ500403 100 µg
EUR 703.2

Anti-CCR4 Antibody (Biotin)

STJ500406 100 µg
EUR 703.2

Anti-CCR5 Antibody (Biotin)

STJ500412 100 µg
EUR 703.2

Anti-CCR6 Antibody (Biotin)

STJ500416 100 µg
EUR 703.2

Anti-CCR5 Antibody (Biotin)

STJ500418 100 µg
EUR 703.2

Anti-CCR7 Antibody BIOTIN

STJ500421 100 µg
EUR 703.2

Anti-CD19 Antibody (Biotin)

STJ500433 100 µg
EUR 703.2

Anti-CD3E Antibody (Biotin)

STJ500452 100 µg
EUR 703.2

Anti-CD3E Antibody (Biotin)

STJ500454 100 µg
EUR 703.2

Anti-CD3E Antibody (Biotin)

STJ500456 100 µg
EUR 703.2

Anti-CD3E Antibody (Biotin)

STJ500458 100 µg
EUR 703.2

Anti-CD36 Antibody (Biotin)

STJ500464 100 µg
EUR 703.2

Anti-CD3G Antibody (Biotin)

STJ500466 100 µg
EUR 703.2

Anti-CD47 Antibody (Biotin)

STJ500475 100 µg
EUR 703.2

Anti-CD56 Antibody BIOTIN

STJ500478 100 µg
EUR 703.2

Anti-CD68 Antibody BIOTIN

STJ500481 100 µg
EUR 703.2

Anti-CD80 Antibody BIOTIN

STJ500484 100 µg
EUR 703.2

Anti-CD86 Antibody (Biotin)

STJ500487 100 µg
EUR 703.2

Anti-CD99 Antibody BIOTIN

STJ500491 100 µg
EUR 703.2

Anti-CD99 Antibody BIOTIN

STJ500493 100 µg
EUR 703.2

Anti-CDX2 Antibody (Biotin)

STJ500497 100 µg
EUR 703.2

Anti-SSH1 Antibody (Biotin)

STJ503048 100 µg
EUR 703.2

Anti-SMOX Antibody BIOTIN

STJ503072 100 µg
EUR 703.2

Anti-NAPA Antibody (Biotin)

STJ503075 100 µg
EUR 703.2

Anti-SOX2 Antibody BIOTIN

STJ503094 100 µg
EUR 703.2

Anti-SOX2 Antibody BIOTIN

STJ503096 100 µg
EUR 703.2

Here, we demonstrate for the first time that histone H3K 4 SETD1A methyltransferase is the main regulator of the proliferation of metastatic CRPC (mCRPC). SETD1A expression was significantly correlated with survival rate of patients with prostate cancer.